Jiao X - Search Results

1

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

Jiao X, Kopecky DJ, Liu J, Liu J, Jaen JC, Cardozo MG, Sharma R, Walker N, Wesche H, Li S, Farrelly E, Xiao SH, Wang Z, Kayser F. Jiao X, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7. doi: 10.1016/j.bmcl.2012.08.020. Epub 2012 Aug 10. Bioorg Med Chem Lett. 2012. PMID: 22929232

2

Discovery of a new binding mode for a series of liver X receptor agonists.

Kopecky DJ, Jiao XY, Fisher B, McKendry S, Labelle M, Piper DE, Coward P, Shiau AK, Escaron P, Danao J, Chai A, Jaen J, Kayser F. Kopecky DJ, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2407-10. doi: 10.1016/j.bmcl.2012.02.028. Epub 2012 Feb 20. Bioorg Med Chem Lett. 2012. PMID: 22406115

3

An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1.

Xiao SH, Farrelly E, Anzola J, Crawford D, Jiao X, Liu J, Ayres M, Li S, Huang L, Sharma R, Kayser F, Wesche H, Young SW. Xiao SH, et al. Among authors: jiao x. Anal Biochem. 2007 Aug 15;367(2):179-89. doi: 10.1016/j.ab.2007.05.007. Epub 2007 May 10. Anal Biochem. 2007. PMID: 17592719

4

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Kopecky DJ, Hao X, Chen Y, Fu J, Jiao X, Jaen JC, Cardozo MG, Liu J, Wang Z, Walker NP, Wesche H, Li S, Farrelly E, Xiao SH, Kayser F. Kopecky DJ, et al. Among authors: jiao x. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6352-6. doi: 10.1016/j.bmcl.2008.10.092. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993068

5

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

Rew Y, Sun D, Gonzalez-Lopez De Turiso F, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Deignan J, Fox BM, Gustin D, Huang X, Jiang M, Jiao X, Jin L, Kayser F, Kopecky DJ, Li Y, Lo MC, Long AM, Michelsen K, Oliner JD, Osgood T, Ragains M, Saiki AY, Schneider S, Toteva M, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH. Rew Y, et al. Among authors: jiao x. J Med Chem. 2012 Jun 14;55(11):4936-54. doi: 10.1021/jm300354j. Epub 2012 May 9. J Med Chem. 2012. PMID: 22524527

6

Discovery and optimization of a series of liver X receptor antagonists.

Jiao X, Kopecky DJ, Fisher B, Piper DE, Labelle M, McKendry S, Harrison M, Jones S, Jaen J, Shiau AK, Escaron P, Danao J, Chai A, Coward P, Kayser F. Jiao X, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5966-70. doi: 10.1016/j.bmcl.2012.07.048. Epub 2012 Jul 21. Bioorg Med Chem Lett. 2012. PMID: 22901900

7

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators.

Wang Y, Jiao X, Kayser F, Liu J, Wang Z, Wanska M, Greenberg J, Weiszmann J, Ge H, Tian H, Wong S, Schwandner R, Lee T, Li Y. Wang Y, et al. Among authors: jiao x. Bioorg Med Chem Lett. 2010 Jan 15;20(2):493-8. doi: 10.1016/j.bmcl.2009.11.112. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20005104

8

Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2.

Lee T, Schwandner R, Swaminath G, Weiszmann J, Cardozo M, Greenberg J, Jaeckel P, Ge H, Wang Y, Jiao X, Liu J, Kayser F, Tian H, Li Y. Lee T, et al. Among authors: jiao x. Mol Pharmacol. 2008 Dec;74(6):1599-609. doi: 10.1124/mol.108.049536. Epub 2008 Sep 25. Mol Pharmacol. 2008. PMID: 18818303

9

5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.

Kohn TJ, Du X, Lai S, Xiong Y, Komorowski R, Veniant M, Fu Z, Jiao X, Pattaropong V, Chow D, Cardozo M, Jin L, Conn M, DeWolf WE Jr, Kraser CF, Hinklin RJ, Boys ML, Medina JC, Houze J, Dransfield P, Coward P. Kohn TJ, et al. Among authors: jiao x. ACS Med Chem Lett. 2016 Jun 1;7(7):666-70. doi: 10.1021/acsmedchemlett.6b00145. eCollection 2016 Jul 14. ACS Med Chem Lett. 2016. PMID: 27437074 Free PMC article.

10

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.

Brown SP, Dransfield PJ, Vimolratana M, Jiao X, Zhu L, Pattaropong V, Sun Y, Liu J, Luo J, Zhang J, Wong S, Zhuang R, Guo Q, Li F, Medina JC, Swaminath G, Lin DC, Houze JB. Brown SP, et al. Among authors: jiao x. ACS Med Chem Lett. 2012 Aug 15;3(9):726-30. doi: 10.1021/ml300133f. eCollection 2012 Sep 13. ACS Med Chem Lett. 2012. PMID: 24900539 Free PMC article.

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