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KHC-4 anti-cancer effects on human PC3 prostate cancer cell line.
Hwang JM, Ting WJ, Wu HC, Chen YJ, Tsai FJ, Chen PY, Liu CY, Chou LC, Kuo SC, Huang CY. Hwang JM, et al. Among authors: chou lc. Am J Chin Med. 2012;40(5):1063-71. doi: 10.1142/S0192415X12500784. Am J Chin Med. 2012. PMID: 22928835
The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells.
Chou LC, Yang JS, Huang LJ, Wu HC, Lu CC, Chiang JH, Chen KT, Kuo SC, Chung JG. Chou LC, et al. J Gastroenterol. 2009;44(10):1055-63. doi: 10.1007/s00535-009-0111-1. Epub 2009 Aug 14. J Gastroenterol. 2009. PMID: 19688288
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC. Huang SM, et al. Among authors: chou lc. Int J Oncol. 2011 May;38(5):1357-64. doi: 10.3892/ijo.2011.952. Epub 2011 Feb 22. Int J Oncol. 2011. PMID: 21344160
82 results