Douthwaite S - Search Results

1

Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S. Andersen NM, et al. Among authors: douthwaite s. Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27. Antimicrob Agents Chemother. 2012. PMID: 22926570 Free PMC article.

2

Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA.

Douthwaite S, Hansen LH, Mauvais P. Douthwaite S, et al. Mol Microbiol. 2000 Apr;36(1):183-93. doi: 10.1046/j.1365-2958.2000.01841.x. Mol Microbiol. 2000. PMID: 10760175 Free article.

3

Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Xiong L, Kloss P, Douthwaite S, Andersen NM, Swaney S, Shinabarger DL, Mankin AS. Xiong L, et al. Among authors: douthwaite s. J Bacteriol. 2000 Oct;182(19):5325-31. doi: 10.1128/JB.182.19.5325-5331.2000. J Bacteriol. 2000. PMID: 10986233 Free PMC article.

4

Macrolide resistance conferred by base substitutions in 23S rRNA.

Vester B, Douthwaite S. Vester B, et al. Among authors: douthwaite s. Antimicrob Agents Chemother. 2001 Jan;45(1):1-12. doi: 10.1128/AAC.45.1.1-12.2001. Antimicrob Agents Chemother. 2001. PMID: 11120937 Free PMC article. Review. No abstract available.

5

Structure-activity relationships of ketolides vs. macrolides.

Douthwaite S. Douthwaite S. Clin Microbiol Infect. 2001;7 Suppl 3:11-7. Clin Microbiol Infect. 2001. PMID: 11523556 Free article. Review.

6

Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site.

Douthwaite S, Champney WS. Douthwaite S, et al. J Antimicrob Chemother. 2001 Sep;48 Suppl T1:1-8. doi: 10.1093/jac/48.suppl_2.1. J Antimicrob Chemother. 2001. PMID: 11566971 Review.

7

Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

Liu M, Douthwaite S. Liu M, et al. Among authors: douthwaite s. Antimicrob Agents Chemother. 2002 Jun;46(6):1629-33. doi: 10.1128/AAC.46.6.1629-1633.2002. Antimicrob Agents Chemother. 2002. PMID: 12019067 Free PMC article.

8

Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.

Liu M, Douthwaite S. Liu M, et al. Among authors: douthwaite s. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. doi: 10.1073/pnas.232580599. Epub 2002 Nov 4. Proc Natl Acad Sci U S A. 2002. PMID: 12417742 Free PMC article.

9

The macrolide binding site on the bacterial ribosome.

Poehlsgaard J, Douthwaite S. Poehlsgaard J, et al. Among authors: douthwaite s. Curr Drug Targets Infect Disord. 2002 Mar;2(1):67-78. doi: 10.2174/1568005024605927. Curr Drug Targets Infect Disord. 2002. PMID: 12462154 Review.

10

Macrolide antibiotic interaction and resistance on the bacterial ribosome.

Poehlsgaard J, Douthwaite S. Poehlsgaard J, et al. Among authors: douthwaite s. Curr Opin Investig Drugs. 2003 Feb;4(2):140-8. Curr Opin Investig Drugs. 2003. PMID: 12669373 Review.

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