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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. Sasaki M, et al. Among authors: ten ay. Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27. Genes Dev. 2012. PMID: 22925884 Free PMC article.
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.
Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, Huang P, Sawyer SK, Fuerth B, Faubert B, Kalliomäki T, Elia A, Luo X, Nadeem V, Bungard D, Yalavarthi S, Growney JD, Wakeham A, Moolani Y, Silvester J, Ten AY, Bakker W, Tsuchihara K, Berger SL, Hill RP, Jones RG, Tsao M, Robinson MO, Thompson CB, Pan G, Mak TW. Zaugg K, et al. Among authors: ten ay. Genes Dev. 2011 May 15;25(10):1041-51. doi: 10.1101/gad.1987211. Genes Dev. 2011. PMID: 21576264 Free PMC article.