Gladyshev VN - Search Results

1

On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan.

Gladyshev VN. Gladyshev VN. Bioessays. 2012 Nov;34(11):925-9. doi: 10.1002/bies.201200092. Epub 2012 Aug 23. Bioessays. 2012. PMID: 22915358 Free PMC article. Review.

2

The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan.

Gladyshev VN. Gladyshev VN. Trends Genet. 2013 Sep;29(9):506-12. doi: 10.1016/j.tig.2013.05.004. Epub 2013 Jun 13. Trends Genet. 2013. PMID: 23769208 Free PMC article.

3

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Ogrodnik M, Salmonowicz H, Gladyshev VN. Ogrodnik M, et al. Among authors: gladyshev vn. Aging Cell. 2019 Feb;18(1):e12841. doi: 10.1111/acel.12841. Epub 2018 Oct 22. Aging Cell. 2019. PMID: 30346102 Free PMC article. Review.

4

Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces.

Marino SM, Gladyshev VN. Marino SM, et al. Among authors: gladyshev vn. J Mol Biol. 2010 Dec 17;404(5):902-16. doi: 10.1016/j.jmb.2010.09.027. Epub 2010 Oct 13. J Mol Biol. 2010. PMID: 20950627 Free PMC article.

5

Role of reactive oxygen species-mediated signaling in aging.

Labunskyy VM, Gladyshev VN. Labunskyy VM, et al. Among authors: gladyshev vn. Antioxid Redox Signal. 2013 Oct 20;19(12):1362-72. doi: 10.1089/ars.2012.4891. Epub 2012 Sep 20. Antioxid Redox Signal. 2013. PMID: 22901002 Free PMC article. Review.

6

The free radical theory of aging is dead. Long live the damage theory!

Gladyshev VN. Gladyshev VN. Antioxid Redox Signal. 2014 Feb 1;20(4):727-31. doi: 10.1089/ars.2013.5228. Epub 2013 Dec 4. Antioxid Redox Signal. 2014. PMID: 24159899 Free PMC article.

7

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.

Avanesov AS, Ma S, Pierce KA, Yim SH, Lee BC, Clish CB, Gladyshev VN. Avanesov AS, et al. Among authors: gladyshev vn. Elife. 2014 Apr 29;3:e02077. doi: 10.7554/eLife.02077. Elife. 2014. PMID: 24843015 Free PMC article.

8

Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.

Kaya A, Lobanov AV, Gladyshev VN. Kaya A, et al. Among authors: gladyshev vn. Aging Cell. 2015 Jun;14(3):366-71. doi: 10.1111/acel.12290. Epub 2015 Feb 22. Aging Cell. 2015. PMID: 25702753 Free PMC article.

9

DNA repair in species with extreme lifespan differences.

MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J. MacRae SL, et al. Among authors: gladyshev vn. Aging (Albany NY). 2015 Dec;7(12):1171-84. doi: 10.18632/aging.100866. Aging (Albany NY). 2015. PMID: 26729707 Free PMC article.

10

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coşkun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V. Patrick A, et al. Among authors: gladyshev vn. Aging (Albany NY). 2016 May;8(5):841-7. doi: 10.18632/aging.100958. Aging (Albany NY). 2016. PMID: 27163160 Free PMC article.

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