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Single-stranded microRNA mimics.
Chorn G, Klein-McDowell M, Zhao L, Saunders MA, Flanagan WM, Willingham AT, Lim LP. Chorn G, et al. Among authors: flanagan wm. RNA. 2012 Oct;18(10):1796-804. doi: 10.1261/rna.031278.111. Epub 2012 Aug 21. RNA. 2012. PMID: 22912485 Free PMC article.
mRNA knockdown by single strand RNA is improved by chemical modifications.
Haringsma HJ, Li JJ, Soriano F, Kenski DM, Flanagan WM, Willingham AT. Haringsma HJ, et al. Among authors: flanagan wm. Nucleic Acids Res. 2012 May;40(9):4125-36. doi: 10.1093/nar/gkr1301. Epub 2012 Jan 16. Nucleic Acids Res. 2012. PMID: 22253019 Free PMC article.
siRNA-optimized Modifications for Enhanced In Vivo Activity.
Kenski DM, Butora G, Willingham AT, Cooper AJ, Fu W, Qi N, Soriano F, Davies IW, Flanagan WM. Kenski DM, et al. Among authors: flanagan wm. Mol Ther Nucleic Acids. 2012 Jan 24;1(1):e5. doi: 10.1038/mtna.2011.4. Mol Ther Nucleic Acids. 2012. PMID: 23344622 Free PMC article.
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.
Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, Mathur M, Sachs AB, Flanagan WM. Kenski DM, et al. Among authors: flanagan wm. Nucleic Acids Res. 2010 Jan;38(2):660-71. doi: 10.1093/nar/gkp913. Epub 2009 Nov 16. Nucleic Acids Res. 2010. PMID: 19917641 Free PMC article.
RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.
Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA. Wei J, et al. Among authors: flanagan wm. Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22. Mol Pharmacol. 2011. PMID: 21427169
Small-molecule inhibition of TNF-alpha.
He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC. He MM, et al. Among authors: flanagan wm. Science. 2005 Nov 11;310(5750):1022-5. doi: 10.1126/science.1116304. Science. 2005. PMID: 16284179
173 results