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β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME. Cai J, et al. Among authors: grant mb. EMBO Mol Med. 2012 Sep;4(9):980-91. doi: 10.1002/emmm.201101084. Epub 2012 Aug 20. EMBO Mol Med. 2012. PMID: 22903875 Free PMC article.
Retinal and choroidal microangiopathies: therapeutic opportunities.
Afzal A, Shaw LC, Ljubimov AV, Boulton ME, Segal MS, Grant MB. Afzal A, et al. Among authors: grant mb. Microvasc Res. 2007 Sep-Nov;74(2-3):131-44. doi: 10.1016/j.mvr.2007.04.011. Epub 2007 May 21. Microvasc Res. 2007. PMID: 17585951 Review.
gamma-Secretase: a multifaceted regulator of angiogenesis.
Boulton ME, Cai J, Grant MB. Boulton ME, et al. Among authors: grant mb. J Cell Mol Med. 2008 Jun;12(3):781-95. doi: 10.1111/j.1582-4934.2008.00274.x. Epub 2008 Feb 8. J Cell Mol Med. 2008. PMID: 18266961 Free PMC article. Review.
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.
Sengupta N, Caballero S, Sullivan SM, Chang LJ, Afzal A, Li Calzi S, Kielczewski JL, Prabarakan S, Ellis EA, Moldovan L, Moldovan NI, Boulton ME, Grant MB, Scott EW, Harris JR. Sengupta N, et al. Among authors: grant mb. Mol Ther. 2009 Sep;17(9):1594-604. doi: 10.1038/mt.2009.145. Epub 2009 Jul 7. Mol Ther. 2009. PMID: 19584817 Free PMC article.
Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation.
Kielczewski JL, Jarajapu YP, McFarland EL, Cai J, Afzal A, Li Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Boulton ME, Mames RN, Chan-Ling T, Grant MB. Kielczewski JL, et al. Among authors: grant mb. Circ Res. 2009 Oct 23;105(9):897-905. doi: 10.1161/CIRCRESAHA.109.199059. Epub 2009 Sep 17. Circ Res. 2009. PMID: 19762684 Free PMC article.
276 results