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408 results

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Rac1 in the driver's seat for melanoma.
Machesky LM, Sansom OJ. Machesky LM, et al. Among authors: sansom oj. Pigment Cell Melanoma Res. 2012 Nov;25(6):762-4. doi: 10.1111/pcmr.12004. Pigment Cell Melanoma Res. 2012. PMID: 22882909 No abstract available.
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Lindsay CR, et al. Among authors: sansom oj. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. Nat Commun. 2011. PMID: 22109529 Free PMC article.
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ. Myant KB, et al. Among authors: sansom oj. Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9. Cell Stem Cell. 2013. PMID: 23665120 Free PMC article.
Rac1 drives intestinal stem cell proliferation and regeneration.
Myant KB, Scopelliti A, Haque S, Vidal M, Sansom OJ, Cordero JB. Myant KB, et al. Among authors: sansom oj. Cell Cycle. 2013 Sep 15;12(18):2973-7. doi: 10.4161/cc.26031. Epub 2013 Aug 12. Cell Cycle. 2013. PMID: 23974108 Free PMC article.
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM. Li A, et al. Among authors: sansom oj. Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23. Gastroenterology. 2014. PMID: 24462734 Free PMC article.
A Rac1-independent role for P-Rex1 in melanoblasts.
Lindsay CR, Li A, Faller W, Ozanne B, Welch H, Machesky LM, Sansom OJ. Lindsay CR, et al. Among authors: sansom oj. J Invest Dermatol. 2015 Jan;135(1):314-318. doi: 10.1038/jid.2014.323. Epub 2014 Jul 30. J Invest Dermatol. 2015. PMID: 25075639 Free PMC article. No abstract available.
408 results