Ruf S - Search Results

1

Novel β-amino acid derivatives as inhibitors of cathepsin A.

Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A, Kohlmann M, Linz D, Hübschle T, Rütten H, Wirth K, Schmidt T, Sadowski T. Ruf S, et al. J Med Chem. 2012 Sep 13;55(17):7636-49. doi: 10.1021/jm300663n. Epub 2012 Aug 16. J Med Chem. 2012. PMID: 22861813

2

Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.

Keil S, Müller M, Zoller G, Haschke G, Schroeter K, Glien M, Ruf S, Focken I, Herling AW, Schmoll D. Keil S, et al. Among authors: ruf s. J Med Chem. 2010 Dec 23;53(24):8679-87. doi: 10.1021/jm101179e. Epub 2010 Nov 17. J Med Chem. 2010. PMID: 21082864

3

Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats.

Daniels A, Linz D, van Bilsen M, Rütten H, Sadowski T, Ruf S, Juretschke HP, Neumann-Haefelin C, Munts C, van der Vusse GJ, van Nieuwenhoven FA. Daniels A, et al. Among authors: ruf s. Eur J Heart Fail. 2012 Feb;14(2):193-201. doi: 10.1093/eurjhf/hfr166. Eur J Heart Fail. 2012. PMID: 22253456 Free article.

4

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M. Zech G, et al. Among authors: ruf s. J Med Chem. 2012 Oct 25;55(20):8615-29. doi: 10.1021/jm300771j. Epub 2012 Oct 4. J Med Chem. 2012. PMID: 22984835

5

Inhibition of CatA: an emerging strategy for the treatment of heart failure.

Ruf S, Buning C, Schreuder H, Linz W, Hübschle T, Linz D, Ruetten H, Wirth K, Sadowski T. Ruf S, et al. Future Med Chem. 2013 Mar;5(4):399-409. doi: 10.4155/fmc.13.24. Future Med Chem. 2013. PMID: 23495688

6

Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.

Schreuder HA, Liesum A, Kroll K, Böhnisch B, Buning C, Ruf S, Sadowski T. Schreuder HA, et al. Among authors: ruf s. Biochem Biophys Res Commun. 2014 Mar 7;445(2):451-6. doi: 10.1016/j.bbrc.2014.02.014. Epub 2014 Feb 12. Biochem Biophys Res Commun. 2014. PMID: 24530914

7

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.

Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, Güssregen S, Riedel J, Herling AW, von Knethen A, Weigert A, Brüne B, Schmoll D. Winkel AF, et al. Among authors: ruf s. J Biol Chem. 2015 Nov 20;290(47):28446-28455. doi: 10.1074/jbc.M115.678136. Epub 2015 Oct 12. J Biol Chem. 2015. PMID: 26459563 Free PMC article.

8

Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats.

Linz D, Hohl M, Dhein S, Ruf S, Reil JC, Kabiri M, Wohlfart P, Verheule S, Böhm M, Sadowski T, Schotten U. Linz D, et al. Among authors: ruf s. Cardiovasc Res. 2016 Jun 1;110(3):371-80. doi: 10.1093/cvr/cvw071. Epub 2016 Mar 31. Cardiovasc Res. 2016. PMID: 27032673

9

Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.

Tillner J, Lehmann A, Paehler T, Lukacs Z, Ruf S, Sadowski T, Pinquier JL, Ruetten H. Tillner J, et al. Among authors: ruf s. Clin Pharmacol Drug Dev. 2016 Jan;5(1):57-68. doi: 10.1002/cpdd.201. Epub 2015 Sep 24. Clin Pharmacol Drug Dev. 2016. PMID: 27119579 Clinical Trial.

10

Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.

Petrera A, Gassenhuber J, Ruf S, Gunasekaran D, Esser J, Shahinian JH, Hübschle T, Rütten H, Sadowski T, Schilling O. Petrera A, et al. Among authors: ruf s. J Transl Med. 2016 May 31;14(1):153. doi: 10.1186/s12967-016-0907-8. J Transl Med. 2016. PMID: 27246731 Free PMC article.

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