Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability.
Alonso AD, Cohen LS, Corbo C, Morozova V, ElIdrissi A, Phillips G, Kleiman FE.
Alonso AD, et al.
Front Cell Neurosci. 2018 Oct 9;12:338. doi: 10.3389/fncel.2018.00338. eCollection 2018.
Front Cell Neurosci. 2018.
PMID: 30356756
Free PMC article.
Review.
Tau is a neuronal microtubule associated protein whose main biological functions are to promote microtubule self-assembly by tubulin and to stabilize those already formed. ...Tau post-translational modifications (PTMs) are responsible for its gain of toxic function. Alo …
Tau is a neuronal microtubule associated protein whose main biological functions are to promote microtubule self-assembly by tubulin …