Seco EM - Search Results

1

Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage.

Aquilino C, Gonzalez Rubio ML, Seco EM, Escudero L, Corvo L, Soto M, Fresno M, Malpartida F, Bonay P. Aquilino C, et al. Among authors: seco em. PLoS One. 2012;7(7):e40901. doi: 10.1371/journal.pone.0040901. Epub 2012 Jul 31. PLoS One. 2012. PMID: 22859958 Free PMC article.

2

New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.

Escudero L, Al-Refai M, Nieto C, Laatsch H, Malpartida F, Seco EM. Escudero L, et al. Among authors: seco em. PLoS One. 2015 Aug 18;10(8):e0135891. doi: 10.1371/journal.pone.0135891. eCollection 2015. PLoS One. 2015. PMID: 26284936 Free PMC article.

3

CE-108, a new macrolide tetraene antibiotic.

Pérez-Zúñiga FJ, Seco EM, Cuesta T, Degenhardt F, Rohr J, Vallín C, Iznaga Y, Pérez ME, González L, Malpartida F. Pérez-Zúñiga FJ, et al. Among authors: seco em. J Antibiot (Tokyo). 2004 Mar;57(3):197-204. doi: 10.7164/antibiotics.57.197. J Antibiot (Tokyo). 2004. PMID: 15152805 Free article.

4

Selective activity of polyene macrolides produced by genetically modified Streptomyces on Trypanosoma cruzi.

Rolón M, Seco EM, Vega C, Nogal JJ, Escario JA, Gómez-Barrio A, Malpartida F. Rolón M, et al. Among authors: seco em. Int J Antimicrob Agents. 2006 Aug;28(2):104-9. doi: 10.1016/j.ijantimicag.2006.02.025. Epub 2006 Jul 17. Int J Antimicrob Agents. 2006. PMID: 16844353

5

Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.

Seco EM, Pérez-Zúñiga FJ, Rolón MS, Malpartida F. Seco EM, et al. Chem Biol. 2004 Mar;11(3):357-66. doi: 10.1016/j.chembiol.2004.02.017. Chem Biol. 2004. PMID: 15123265

6

Two polyene amides produced by genetically modified Streptomyces diastaticus var. 108.

Seco EM, Cuesta T, Fotso S, Laatsch H, Malpartida F. Seco EM, et al. Chem Biol. 2005 May;12(5):535-43. doi: 10.1016/j.chembiol.2005.02.015. Chem Biol. 2005. PMID: 15911374

7

A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.

Seco EM, Fotso S, Laatsch H, Malpartida F. Seco EM, et al. Chem Biol. 2005 Oct;12(10):1093-101. doi: 10.1016/j.chembiol.2005.08.007. Chem Biol. 2005. PMID: 16242652

8

Isolation and characterization of pcsB, the gene for a polyene carboxamide synthase that tailors pimaricin into AB-400.

Miranzo D, Seco EM, Cuesta T, Malpartida F. Miranzo D, et al. Among authors: seco em. Appl Microbiol Biotechnol. 2010 Feb;85(6):1809-19. doi: 10.1007/s00253-009-2195-1. Epub 2009 Aug 26. Appl Microbiol Biotechnol. 2010. PMID: 19707754

9

The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis.

Seco EM, Miranzo D, Nieto C, Malpartida F. Seco EM, et al. Appl Microbiol Biotechnol. 2010 Feb;85(6):1797-807. doi: 10.1007/s00253-009-2193-3. Epub 2009 Aug 26. Appl Microbiol Biotechnol. 2010. PMID: 19707755

10

Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.

Heia S, Borgos SE, Sletta H, Escudero L, Seco EM, Malpartida F, Ellingsen TE, Zotchev SB. Heia S, et al. Among authors: seco em. Appl Environ Microbiol. 2011 Oct;77(19):6982-90. doi: 10.1128/AEM.05781-11. Epub 2011 Aug 5. Appl Environ Microbiol. 2011. PMID: 21821762 Free PMC article.

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