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Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Ellerby LM, et al. Among authors: hayden mr. J Biol Chem. 1999 Mar 26;274(13):8730-6. doi: 10.1074/jbc.274.13.8730. J Biol Chem. 1999. PMID: 10085113 Free article.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: hayden mr. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S, Nicholson DW. Rasper DM, et al. Among authors: hayden mr. Cell Death Differ. 1998 Apr;5(4):271-88. doi: 10.1038/sj.cdd.4400370. Cell Death Differ. 1998. PMID: 10200473
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Hermel E, et al. Among authors: hayden mr. Cell Death Differ. 2004 Apr;11(4):424-38. doi: 10.1038/sj.cdd.4401358. Cell Death Differ. 2004. PMID: 14713958
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E. Rigamonti D, et al. Among authors: hayden mr. J Neurosci. 2000 May 15;20(10):3705-13. doi: 10.1523/JNEUROSCI.20-10-03705.2000. J Neurosci. 2000. PMID: 10804212 Free PMC article.
900 results