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A long-term prospective population pharmacokinetic study on imatinib plasma concentrations in GIST patients.
Eechoute K, Fransson MN, Reyners AK, de Jong FA, Sparreboom A, van der Graaf WT, Friberg LE, Schiavon G, Wiemer EA, Verweij J, Loos WJ, Mathijssen RH, De Giorgi U. Eechoute K, et al. Among authors: van der graaf wt. Clin Cancer Res. 2012 Oct 15;18(20):5780-7. doi: 10.1158/1078-0432.CCR-12-0490. Epub 2012 Jul 31. Clin Cancer Res. 2012. PMID: 22850565
Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study.
Verweij J, van Oosterom A, Blay JY, Judson I, Rodenhuis S, van der Graaf W, Radford J, Le Cesne A, Hogendoorn PC, di Paola ED, Brown M, Nielsen OS. Verweij J, et al. Eur J Cancer. 2003 Sep;39(14):2006-11. Eur J Cancer. 2003. PMID: 12957454 Clinical Trial.
Imatinib induces hypothyroidism in patients receiving levothyroxine.
de Groot JW, Zonnenberg BA, Plukker JT, van Der Graaf WT, Links TP. de Groot JW, et al. Among authors: van der graaf wt. Clin Pharmacol Ther. 2005 Oct;78(4):433-8. doi: 10.1016/j.clpt.2005.06.010. Clin Pharmacol Ther. 2005. PMID: 16198662 Clinical Trial.
639 results