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Overexpression of activated phospholipase Cγ1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy.
Lattanzio R, Marchisio M, La Sorda R, Tinari N, Falasca M, Alberti S, Miscia S, Ercolani C, Di Benedetto A, Perracchio L, Melucci E, Iacobelli S, Mottolese M, Natali PG, Piantelli M; CINBO (Consorzio Interuniversitario Nazionale per Bio-Oncologia). Lattanzio R, et al. Among authors: falasca m. Int J Cancer. 2013 Mar 1;132(5):1022-31. doi: 10.1002/ijc.27751. Epub 2012 Sep 1. Int J Cancer. 2013. PMID: 22847294
Phospholipase Cgamma1 is required for metastasis development and progression.
Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M, Falasca M. Sala G, et al. Among authors: falasca m. Cancer Res. 2008 Dec 15;68(24):10187-96. doi: 10.1158/0008-5472.CAN-08-1181. Cancer Res. 2008. PMID: 19074886
Role of phospholipase C in cell invasion and metastasis.
Lattanzio R, Piantelli M, Falasca M. Lattanzio R, et al. Among authors: falasca m. Adv Biol Regul. 2013 Sep;53(3):309-18. doi: 10.1016/j.jbior.2013.07.006. Epub 2013 Jul 18. Adv Biol Regul. 2013. PMID: 23925006 Review.
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.
Ferro R, Adamska A, Lattanzio R, Mavrommati I, Edling CE, Arifin SA, Fyffe CA, Sala G, Sacchetto L, Chiorino G, De Laurenzi V, Piantelli M, Sansom OJ, Maffucci T, Falasca M. Ferro R, et al. Among authors: falasca m. Oncogene. 2018 Dec;37(49):6368-6382. doi: 10.1038/s41388-018-0390-1. Epub 2018 Jul 30. Oncogene. 2018. PMID: 30061636
ABCC3 is a novel target for the treatment of pancreatic cancer.
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, Chiorino G, Akkaya BG, Linton KJ, De Laurenzi V, Sala G, Falasca M. Adamska A, et al. Among authors: falasca m. Adv Biol Regul. 2019 Aug;73:100634. doi: 10.1016/j.jbior.2019.04.004. Epub 2019 Apr 24. Adv Biol Regul. 2019. PMID: 31053501
176 results