Brignole EJ - Search Results

1

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers.

Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Aye Y, et al. Among authors: brignole ej. Chem Biol. 2012 Jul 27;19(7):799-805. doi: 10.1016/j.chembiol.2012.05.015. Chem Biol. 2012. PMID: 22840768 Free PMC article.

2

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.

Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Ando N, et al. Among authors: brignole ej. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51. doi: 10.1073/pnas.1112715108. Epub 2011 Dec 12. Proc Natl Acad Sci U S A. 2011. PMID: 22160671 Free PMC article.

3

The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.

Brignole EJ, Ando N, Zimanyi CM, Drennan CL. Brignole EJ, et al. Biochem Soc Trans. 2012 Jun 1;40(3):523-30. doi: 10.1042/BST20120081. Biochem Soc Trans. 2012. PMID: 22616862 Free PMC article. Review.

4

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. Zimanyi CM, et al. Among authors: brignole ej. Structure. 2012 Aug 8;20(8):1374-83. doi: 10.1016/j.str.2012.05.009. Epub 2012 Jun 21. Structure. 2012. PMID: 22727814 Free PMC article.

5

Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase.

Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Minnihan EC, et al. Among authors: brignole ej. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3835-40. doi: 10.1073/pnas.1220691110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431160 Free PMC article.

6

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. Brignole EJ, et al. Elife. 2018 Feb 20;7:e31502. doi: 10.7554/eLife.31502. Elife. 2018. PMID: 29460780 Free PMC article.

7

Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.

Chen PY, Funk MA, Brignole EJ, Drennan CL. Chen PY, et al. Among authors: brignole ej. J Biol Chem. 2018 Jun 29;293(26):10404-10412. doi: 10.1074/jbc.RA118.002569. Epub 2018 Apr 26. J Biol Chem. 2018. PMID: 29700111 Free PMC article.

8

Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.

Levitz TS, Brignole EJ, Fong I, Darrow MC, Drennan CL. Levitz TS, et al. Among authors: brignole ej. J Struct Biol. 2022 Mar;214(1):107825. doi: 10.1016/j.jsb.2021.107825. Epub 2021 Dec 11. J Struct Biol. 2022. PMID: 34906669 Free PMC article.

9

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.

Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Ando N, et al. Among authors: brignole ej. Biochemistry. 2016 Jan 19;55(2):373-81. doi: 10.1021/acs.biochem.5b01207. Epub 2016 Jan 4. Biochemistry. 2016. PMID: 26727048 Free PMC article.

10

The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism.

Gibson MI, Brignole EJ, Pierce E, Can M, Ragsdale SW, Drennan CL. Gibson MI, et al. Among authors: brignole ej. Biochemistry. 2015 Jul 7;54(26):4112-20. doi: 10.1021/acs.biochem.5b00521. Epub 2015 Jun 24. Biochemistry. 2015. PMID: 26061898 Free PMC article.

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