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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK; ALT Starr Cancer Consortium. Lovejoy CA, et al. Among authors: hahn wc. PLoS Genet. 2012;8(7):e1002772. doi: 10.1371/journal.pgen.1002772. Epub 2012 Jul 19. PLoS Genet. 2012. PMID: 22829774 Free PMC article.
Regulating TERT: location, location, location.
Rosenbluh J, Nijhawan D, Hahn WC. Rosenbluh J, et al. Among authors: hahn wc. Cell Cycle. 2009 Oct 15;8(20):3257. doi: 10.4161/cc.8.20.10037. Epub 2009 Oct 15. Cell Cycle. 2009. PMID: 19823010 Free article. No abstract available.
RMRP is a non-coding RNA essential for early murine development.
Rosenbluh J, Nijhawan D, Chen Z, Wong KK, Masutomi K, Hahn WC. Rosenbluh J, et al. Among authors: hahn wc. PLoS One. 2011;6(10):e26270. doi: 10.1371/journal.pone.0026270. Epub 2011 Oct 19. PLoS One. 2011. PMID: 22039455 Free PMC article.
Cancer vulnerabilities unveiled by genomic loss.
Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Nijhawan D, et al. Among authors: hahn wc. Cell. 2012 Aug 17;150(4):842-54. doi: 10.1016/j.cell.2012.07.023. Cell. 2012. PMID: 22901813 Free PMC article.
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
Hagerstrand D, Tong A, Schumacher SE, Ilic N, Shen RR, Cheung HW, Vazquez F, Shrestha Y, Kim SY, Giacomelli AO, Rosenbluh J, Schinzel AC, Spardy NA, Barbie DA, Mermel CH, Weir BA, Garraway LA, Tamayo P, Mesirov JP, Beroukhim R, Hahn WC. Hagerstrand D, et al. Among authors: hahn wc. Cancer Discov. 2013 Sep;3(9):1044-57. doi: 10.1158/2159-8290.CD-12-0592. Epub 2013 Jun 13. Cancer Discov. 2013. PMID: 23764425 Free PMC article.
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
Hanna MC, Go C, Roden C, Jones RT, Pochanard P, Javed AY, Javed A, Mondal C, Palescandolo E, Van Hummelen P, Hatton C, Bass AJ, Chun SM, Na DC, Kim TI, Jang SJ, Osarogiagbon RU, Hahn WC, Meyerson M, Garraway LA, MacConaill LE. Hanna MC, et al. Among authors: hahn wc. PLoS One. 2013 Sep 16;8(9):e74950. doi: 10.1371/journal.pone.0074950. eCollection 2013. PLoS One. 2013. PMID: 24066160 Free PMC article.
Genomic insights into WNT/β-catenin signaling.
Rosenbluh J, Wang X, Hahn WC. Rosenbluh J, et al. Among authors: hahn wc. Trends Pharmacol Sci. 2014 Feb;35(2):103-9. doi: 10.1016/j.tips.2013.11.007. Epub 2013 Dec 20. Trends Pharmacol Sci. 2014. PMID: 24365576 Free PMC article. Review.
382 results