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Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
Soubhye J, Aldib I, Elfving B, Gelbcke M, Furtmüller PG, Podrecca M, Conotte R, Colet JM, Rousseau A, Reye F, Sarakbi A, Vanhaeverbeek M, Kauffmann JM, Obinger C, Nève J, Prévost M, Zouaoui Boudjeltia K, Dufrasne F, Van Antwerpen P. Soubhye J, et al. J Med Chem. 2013 May 23;56(10):3943-58. doi: 10.1021/jm4001538. Epub 2013 May 6. J Med Chem. 2013. PMID: 23581551
Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae).
Bensalem S, Soubhye J, Aldib I, Bournine L, Nguyen AT, Vanhaeverbeek M, Rousseau A, Boudjeltia KZ, Sarakbi A, Kauffmann JM, Nève J, Prévost M, Stévigny C, Maiza-Benabdesselam F, Bedjou F, Van Antwerpen P, Duez P. Bensalem S, et al. Among authors: soubhye j. J Ethnopharmacol. 2014 Jun 11;154(2):361-9. doi: 10.1016/j.jep.2014.03.070. Epub 2014 Apr 16. J Ethnopharmacol. 2014. PMID: 24746482
Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.
Aldib I, Gelbcke M, Soubhye J, Prévost M, Furtmüller PG, Obinger C, Elfving B, Alard IC, Roos G, Delporte C, Berger G, Dufour D, Zouaoui Boudjeltia K, Nève J, Dufrasne F, Van Antwerpen P. Aldib I, et al. Among authors: soubhye j. Eur J Med Chem. 2016 Nov 10;123:746-762. doi: 10.1016/j.ejmech.2016.07.053. Epub 2016 Jul 25. Eur J Med Chem. 2016. PMID: 27537923
Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.
Soubhye J, Chikh Alard I, Aldib I, Prévost M, Gelbcke M, De Carvalho A, Furtmüller PG, Obinger C, Flemmig J, Tadrent S, Meyer F, Rousseau A, Nève J, Mathieu V, Zouaoui Boudjeltia K, Dufrasne F, Van Antwerpen P. Soubhye J, et al. J Med Chem. 2017 Aug 10;60(15):6563-6586. doi: 10.1021/acs.jmedchem.7b00285. Epub 2017 Jul 19. J Med Chem. 2017. PMID: 28671460
21 results