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Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D. Chan IH, et al. Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27. Mucosal Immunol. 2014. PMID: 24280935 Free article.
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA. Pflanz S, et al. Among authors: gorman dm. Immunity. 2002 Jun;16(6):779-90. doi: 10.1016/s1074-7613(02)00324-2. Immunity. 2002. PMID: 12121660 Free article.
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP. Chan JR, et al. Among authors: gorman dm. J Exp Med. 2006 Nov 27;203(12):2577-87. doi: 10.1084/jem.20060244. Epub 2006 Oct 30. J Exp Med. 2006. PMID: 17074928 Free PMC article.
IL-25 regulates Th17 function in autoimmune inflammation.
Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ. Kleinschek MA, et al. Among authors: gorman dm. J Exp Med. 2007 Jan 22;204(1):161-70. doi: 10.1084/jem.20061738. Epub 2007 Jan 2. J Exp Med. 2007. PMID: 17200411 Free PMC article.
C17 prevents inflammatory arthritis and associated joint destruction in mice.
Chao C, Joyce-Shaikh B, Grein J, Moshrefi M, Raoufi F, Laface DM, McClanahan TK, Bourne PA, Pierce RH, Gorman DM, Pflanz S. Chao C, et al. Among authors: gorman dm. PLoS One. 2011;6(7):e22256. doi: 10.1371/journal.pone.0022256. Epub 2011 Jul 25. PLoS One. 2011. PMID: 21799806 Free PMC article.
145 results