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Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways.
Iwanaga R, Wang CA, Micalizzi DS, Harrell JC, Jedlicka P, Sartorius CA, Kabos P, Farabaugh SM, Bradford AP, Ford HL. Iwanaga R, et al. Among authors: harrell jc. Breast Cancer Res. 2012 Jul 5;14(4):R100. doi: 10.1186/bcr3219. Breast Cancer Res. 2012. PMID: 22765220 Free PMC article.
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling.
Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Barón AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL. Micalizzi DS, et al. Among authors: harrell jc. J Clin Invest. 2009 Sep;119(9):2678-90. doi: 10.1172/JCI37815. Epub 2009 Aug 24. J Clin Invest. 2009. PMID: 19726885 Free PMC article.
Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch.
Haughian JM, Pinto MP, Harrell JC, Bliesner BS, Joensuu KM, Dye WW, Sartorius CA, Tan AC, Heikkilä P, Perou CM, Horwitz KB. Haughian JM, et al. Among authors: harrell jc. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2742-7. doi: 10.1073/pnas.1106509108. Epub 2011 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 21969591 Free PMC article.
84 results