Brocklehurst SM - Search Results

1

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation.

Brocklehurst SM, Topham CM, Brocklehurst K. Brocklehurst SM, et al. Biochem Soc Trans. 1990 Aug;18(4):598-600. doi: 10.1042/bst0180598. Biochem Soc Trans. 1990. PMID: 2276457 No abstract available.

2

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.

Topham CM, Salih E, Frazao C, Kowlessur D, Overington JP, Thomas M, Brocklehurst SM, Patel M, Thomas EW, Brocklehurst K. Topham CM, et al. Among authors: brocklehurst sm. Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):79-92. doi: 10.1042/bj2800079. Biochem J. 1991. PMID: 1741760 Free PMC article.

3

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Brocklehurst K, Brocklehurst SM, Kowlessur D, O'Driscoll M, Patel G, Salih E, Templeton W, Thomas E, Topham CM, Willenbrock F. Brocklehurst K, et al. Among authors: brocklehurst sm. Biochem J. 1988 Dec 1;256(2):543-58. doi: 10.1042/bj2560543. Biochem J. 1988. PMID: 3223929 Free PMC article.

4

Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simulation of the E-64-beta-trypsin complex.

Sreedharan SK, Verma C, Caves LS, Brocklehurst SM, Gharbia SE, Shah HN, Brocklehurst K. Sreedharan SK, et al. Among authors: brocklehurst sm. Biochem J. 1996 Jun 15;316 ( Pt 3)(Pt 3):777-86. doi: 10.1042/bj3160777. Biochem J. 1996. PMID: 8670152 Free PMC article.

5

Appendix: Analysis of pH-dependent kinetics in up to four reactive hydronic states.

Brocklehurst SM, Brocklehurst K. Brocklehurst SM, et al. Biochem J. 1988 Dec 1;256(2):556-8. doi: 10.1042/bj2560556. Biochem J. 1988. PMID: 16744552 Free PMC article. No abstract available.

6

Protein-protein recognition mediated by a mini-protein domain: possible evolutionary significance.

Brocklehurst SM, Kalia YN, Perham RN. Brocklehurst SM, et al. Trends Biochem Sci. 1994 Sep;19(9):360-1. doi: 10.1016/0968-0004(94)90111-2. Trends Biochem Sci. 1994. PMID: 7985228 No abstract available.

7

The high-resolution structure of the peripheral subunit-binding domain of dihydrolipoamide acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.

Kalia YN, Brocklehurst SM, Hipps DS, Appella E, Sakaguchi K, Perham RN. Kalia YN, et al. Among authors: brocklehurst sm. J Mol Biol. 1993 Mar 5;230(1):323-41. doi: 10.1006/jmbi.1993.1145. J Mol Biol. 1993. PMID: 8450544

8

Prediction of the three-dimensional structures of the biotinylated domain from yeast pyruvate carboxylase and of the lipoylated H-protein from the pea leaf glycine cleavage system: a new automated method for the prediction of protein tertiary structure.

Brocklehurst SM, Perham RN. Brocklehurst SM, et al. Protein Sci. 1993 Apr;2(4):626-39. doi: 10.1002/pro.5560020413. Protein Sci. 1993. PMID: 8518734 Free PMC article.

9

Finding genes in genomic nucleotide sequences by using bioinformatics.

Edwards YJ, Brocklehurst SM. Edwards YJ, et al. Among authors: brocklehurst sm. Methods Mol Biol. 2001;175:235-47. doi: 10.1385/1-59259-235-X:235. Methods Mol Biol. 2001. PMID: 11462838 Review. No abstract available.

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