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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Okaniwa M, Imada T, Ohashi T, Miyazaki T, Arita T, Yabuki M, Sumita A, Tsutsumi S, Higashikawa K, Takagi T, Kawamoto T, Inui Y, Yoshida S, Ishikawa T. Okaniwa M, et al. Among authors: higashikawa k. Bioorg Med Chem. 2012 Aug 1;20(15):4680-92. doi: 10.1016/j.bmc.2012.06.015. Epub 2012 Jun 15. Bioorg Med Chem. 2012. PMID: 22763369
Optically active antifungal azoles. XIII. Synthesis of stereoisomers and metabolites of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).
Ichikawa T, Yamada M, Yamaguchi M, Kitazaki T, Matsushita Y, Higashikawa K, Itoh K. Ichikawa T, et al. Among authors: higashikawa k. Chem Pharm Bull (Tokyo). 2001 Sep;49(9):1110-9. doi: 10.1248/cpb.49.1110. Chem Pharm Bull (Tokyo). 2001. PMID: 11558596 Free article.
[Long-term Quality Control Test of a 68Ge/68Ga Generator].
Tomita S, Higashikawa K, Ueno S, Mizuno Y, Tazawa S, Kuge Y. Tomita S, et al. Among authors: higashikawa k. Kaku Igaku. 2021;58(1):47-58. doi: 10.18893/kakuigaku.tr.2102. Kaku Igaku. 2021. PMID: 34108303 Free article. Japanese.
The squamous cell carcinoma cell line OM-1 retains both p75-dependent stratified epithelial progenitor potential and cancer stem cell properties.
Uetsuki R, Higashikawa K, Okuda S, Yamakado N, Ishida F, Rizqiawan A, Ono S, Takechi M, Mizuta K, Shigeishi H, Kamata N, Tobiume K. Uetsuki R, et al. Among authors: higashikawa k. Biochem Biophys Rep. 2021 May 18;26:101003. doi: 10.1016/j.bbrep.2021.101003. eCollection 2021 Jul. Biochem Biophys Rep. 2021. PMID: 34041369 Free PMC article.
Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment.
Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M. Tomaru U, et al. Among authors: higashikawa k. Am J Pathol. 2021 Jan;191(1):144-156. doi: 10.1016/j.ajpath.2020.10.004. Am J Pathol. 2021. PMID: 33339546 Free article.
115 results