Timms RT - Search Results

1

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

Duncan LM, Timms RT, Zavodszky E, Cano F, Dougan G, Randow F, Lehner PJ. Duncan LM, et al. Among authors: timms rt. PLoS One. 2012;7(6):e39651. doi: 10.1371/journal.pone.0039651. Epub 2012 Jun 22. PLoS One. 2012. PMID: 22745803 Free PMC article.

2

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ. Timms RT, et al. PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278019 Free PMC article.

3

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ. Tchasovnikarova IA, et al. Among authors: timms rt. Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28. Science. 2015. PMID: 26022416 Free PMC article.

4

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ. Timms RT, et al. Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Bioessays. 2016. PMID: 26853531 Review.

5

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ. Timms RT, et al. Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786. Nat Commun. 2016. PMID: 27283361 Free PMC article.

6

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ. van den Boomen DJ, et al. Among authors: timms rt. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16. Proc Natl Acad Sci U S A. 2014. PMID: 25030448 Free PMC article.

7

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites.

Timms RT, Tchasovnikarova IA, Lehner PJ. Timms RT, et al. Nat Protoc. 2019 Jan;14(1):153-170. doi: 10.1038/s41596-018-0087-5. Nat Protoc. 2019. PMID: 30518911

8

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA. Burr SP, et al. Among authors: timms rt. Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27. Cell Metab. 2016. PMID: 27923773 Free PMC article.

9

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.

Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ. Menzies SA, et al. Among authors: timms rt. Elife. 2018 Dec 13;7:e40009. doi: 10.7554/eLife.40009. Elife. 2018. PMID: 30543180 Free PMC article.

10

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

Rapiteanu R, Davis LJ, Williamson JC, Timms RT, Paul Luzio J, Lehner PJ. Rapiteanu R, et al. Among authors: timms rt. Traffic. 2016 Aug;17(8):940-58. doi: 10.1111/tra.12409. Epub 2016 May 25. Traffic. 2016. PMID: 27126989 Free PMC article.

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