Vederas JC - Search Results

1

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Ames BD, et al. Among authors: vederas jc. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11144-9. doi: 10.1073/pnas.1113029109. Epub 2012 Jun 25. Proc Natl Acad Sci U S A. 2012. PMID: 22733743 Free PMC article.

2

Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.

Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. Pillai B, et al. Among authors: vederas jc. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8668-73. doi: 10.1073/pnas.0602537103. Epub 2006 May 24. Proc Natl Acad Sci U S A. 2006. PMID: 16723397 Free PMC article.

3

Drug discovery and natural products: end of an era or an endless frontier?

Li JW, Vederas JC. Li JW, et al. Among authors: vederas jc. Science. 2009 Jul 10;325(5937):161-5. doi: 10.1126/science.1168243. Science. 2009. PMID: 19589993 Review.

4

Complete reconstitution of a highly reducing iterative polyketide synthase.

Ma SM, Li JW, Choi JW, Zhou H, Lee KK, Moorthie VA, Xie X, Kealey JT, Da Silva NA, Vederas JC, Tang Y. Ma SM, et al. Among authors: vederas jc. Science. 2009 Oct 23;326(5952):589-92. doi: 10.1126/science.1175602. Science. 2009. PMID: 19900898 Free PMC article.

5

Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis.

Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein PC, Vederas JC, Tang Y. Zhou H, et al. Among authors: vederas jc. J Am Chem Soc. 2010 Apr 7;132(13):4530-1. doi: 10.1021/ja100060k. J Am Chem Soc. 2010. PMID: 20222707 Free PMC article.

6

Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs.

Zhou H, Qiao K, Gao Z, Vederas JC, Tang Y. Zhou H, et al. Among authors: vederas jc. J Biol Chem. 2010 Dec 31;285(53):41412-21. doi: 10.1074/jbc.M110.183574. Epub 2010 Oct 20. J Biol Chem. 2010. PMID: 20961859 Free PMC article.

7

[Drug discovery and natural products: end of era or an endless frontier?].

Li JW, Vederas JC. Li JW, et al. Among authors: vederas jc. Biomed Khim. 2011 Mar-Apr;57(2):148-60. doi: 10.18097/pbmc20115702148. Biomed Khim. 2011. PMID: 21870600 Review. Russian. No abstract available.

8

A fungal ketoreductase domain that displays substrate-dependent stereospecificity.

Zhou H, Gao Z, Qiao K, Wang J, Vederas JC, Tang Y. Zhou H, et al. Among authors: vederas jc. Nat Chem Biol. 2012 Mar 11;8(4):331-3. doi: 10.1038/nchembio.912. Nat Chem Biol. 2012. PMID: 22406519 Free PMC article.

9

Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates.

Gao Z, Wang J, Norquay AK, Qiao K, Tang Y, Vederas JC. Gao Z, et al. Among authors: vederas jc. J Am Chem Soc. 2013 Feb 6;135(5):1735-8. doi: 10.1021/ja4001823. Epub 2013 Jan 28. J Am Chem Soc. 2013. PMID: 23356934 Free PMC article.

10

LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y. Xu W, et al. Among authors: vederas jc. Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6472-5. doi: 10.1002/anie.201302406. Epub 2013 May 7. Angew Chem Int Ed Engl. 2013. PMID: 23653178 Free PMC article.

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