Ames BD - Search Results

1

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Ames BD, et al. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11144-9. doi: 10.1073/pnas.1113029109. Epub 2012 Jun 25. Proc Natl Acad Sci U S A. 2012. PMID: 22733743 Free PMC article.

2

Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.

Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC. Ames BD, et al. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5349-54. doi: 10.1073/pnas.0709223105. Epub 2008 Apr 3. Proc Natl Acad Sci U S A. 2008. PMID: 18388203 Free PMC article.

3

Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.

Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Ames BD, et al. Biochemistry. 2011 Oct 4;50(39):8392-406. doi: 10.1021/bi200593m. Epub 2011 Sep 8. Biochemistry. 2011. PMID: 21870821 Free PMC article.

4

Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI.

Lee MY, Ames BD, Tsai SC. Lee MY, et al. Among authors: ames bd. Biochemistry. 2012 Apr 10;51(14):3079-91. doi: 10.1021/bi201705q. Epub 2012 Mar 30. Biochemistry. 2012. PMID: 22432862 Free PMC article.

5

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Zhang W, Ames BD, Tsai SC, Tang Y. Zhang W, et al. Among authors: ames bd. Appl Environ Microbiol. 2006 Apr;72(4):2573-80. doi: 10.1128/AEM.72.4.2573-2580.2006. Appl Environ Microbiol. 2006. PMID: 16597959 Free PMC article.

6

Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.

Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Gao X, et al. Among authors: ames bd. J Am Chem Soc. 2011 Mar 2;133(8):2729-41. doi: 10.1021/ja1101085. Epub 2011 Feb 7. J Am Chem Soc. 2011. PMID: 21299212 Free PMC article.

7

Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.

Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Haynes SW, et al. Among authors: ames bd. Biochemistry. 2011 Jun 28;50(25):5668-79. doi: 10.1021/bi2004922. Epub 2011 Jun 2. Biochemistry. 2011. PMID: 21591693 Free PMC article.

8

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.

Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Gao X, et al. Among authors: ames bd. Nat Chem Biol. 2012 Oct;8(10):823-30. doi: 10.1038/nchembio.1047. Nat Chem Biol. 2012. PMID: 22902615 Free PMC article.

9

Structural enzymology of polyketide synthases.

Tsai SC, Ames BD. Tsai SC, et al. Among authors: ames bd. Methods Enzymol. 2009;459:17-47. doi: 10.1016/S0076-6879(09)04602-3. Methods Enzymol. 2009. PMID: 19362634 Free PMC article.

10

Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.

Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Ames BD, et al. Biochemistry. 2011 Oct 11;50(40):8756-69. doi: 10.1021/bi201302w. Epub 2011 Sep 19. Biochemistry. 2011. PMID: 21899262 Free PMC article.

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