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Toxicity as a result of immunostimulation by biologics.
Gribble EJ, Sivakumar PV, Ponce RA, Hughes SD. Gribble EJ, et al. Expert Opin Drug Metab Toxicol. 2007 Apr;3(2):209-34. doi: 10.1517/17425255.3.2.209. Expert Opin Drug Metab Toxicol. 2007. PMID: 17428152 Review.
Interleukin-21 enhances rituximab activity in a cynomolgus monkey model of B cell depletion and in mouse B cell lymphoma models.
Krejsa CM, Holly RD, Heipel M, Bannink KM, Johnson R, Roque R, Heffernan J, Hill J, Chin L, Wagener F, Shiota F, Henderson K, Sivakumar PV, Ren HP, Barahmand-Pour F, Foster D, Clegg C, Kindsvogel W, Ponce R, Hughes SD, Waggie K. Krejsa CM, et al. Among authors: ponce r. PLoS One. 2013 Jun 25;8(6):e67256. doi: 10.1371/journal.pone.0067256. Print 2013. PLoS One. 2013. PMID: 23825648 Free PMC article.
Preclinical safety of recombinant human thrombin.
Heffernan JK, Ponce RA, Zuckerman LA, Volpone JP, Visich J, Giste EE, Jenkins N, Boster D, Pederson S, Knitter G, Palmer T, Wills M, Early RJ, Rogge MC. Heffernan JK, et al. Regul Toxicol Pharmacol. 2007 Feb;47(1):48-58. doi: 10.1016/j.yrtph.2006.07.006. Epub 2006 Sep 12. Regul Toxicol Pharmacol. 2007. PMID: 16971028
Immunomodulation and lymphoma in humans.
Ponce RA, Gelzleichter T, Haggerty HG, Heidel S, Holdren MS, Lebrec H, Mellon RD, Pallardy M. Ponce RA, et al. J Immunotoxicol. 2014 Jan-Mar;11(1):1-12. doi: 10.3109/1547691X.2013.798388. Epub 2013 Jun 7. J Immunotoxicol. 2014. PMID: 23746314 Free article. Review.
Nonclinical safety, pharmacokinetics, and pharmacodynamics of atacicept.
Carbonatto M, Yu P, Bertolino M, Vigna E, Steidler S, Fava L, Daghero C, Roattino B, Onidi M, Ardizzone M, Peano S, Visich J, Janszen D, Dillon S, Ponce R. Carbonatto M, et al. Among authors: ponce r. Toxicol Sci. 2008 Sep;105(1):200-10. doi: 10.1093/toxsci/kfn105. Epub 2008 Jun 2. Toxicol Sci. 2008. PMID: 18522929 Free article.
160 results