Shapiro AB - Search Results

1

An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode.

Larsen NA, Nash TJ, Morningstar M, Shapiro AB, Joubran C, Blackett CJ, Patten AD, Boriack-Sjodin PA, Doig P. Larsen NA, et al. Among authors: shapiro ab. Biochem J. 2012 Sep 15;446(3):405-13. doi: 10.1042/BJ20120596. Biochem J. 2012. PMID: 22721802

2

In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.

Buurman ET, Andrews B, Gao N, Hu J, Keating TA, Lahiri S, Otterbein LR, Patten AD, Stokes SS, Shapiro AB. Buurman ET, et al. Among authors: shapiro ab. J Biol Chem. 2011 Nov 25;286(47):40734-42. doi: 10.1074/jbc.M111.274068. Epub 2011 Oct 7. J Biol Chem. 2011. PMID: 21984832 Free PMC article.

3

Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.

Green OM, McKenzie AR, Shapiro AB, Otterbein L, Ni H, Patten A, Stokes S, Albert R, Kawatkar S, Breed J. Green OM, et al. Among authors: shapiro ab. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1510-9. doi: 10.1016/j.bmcl.2012.01.016. Epub 2012 Jan 14. Bioorg Med Chem Lett. 2012. PMID: 22297115

4

Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.

Rose JA, Lahiri SD, McKinney DC, Albert R, Morningstar ML, Shapiro AB, Fisher SL, Fleming PR. Rose JA, et al. Among authors: shapiro ab. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3301-6. doi: 10.1016/j.bmcl.2015.05.061. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26099541

5

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup GK. Kern G, et al. Among authors: shapiro ab. J Biol Chem. 2015 Aug 21;290(34):20984-20994. doi: 10.1074/jbc.M115.663534. Epub 2015 Jul 6. J Biol Chem. 2015. PMID: 26149691 Free PMC article.

6

Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors.

Shapiro AB, Andrews B. Shapiro AB, et al. Biochem Pharmacol. 2012 Oct 1;84(7):900-4. doi: 10.1016/j.bcp.2012.07.007. Epub 2012 Jul 20. Biochem Pharmacol. 2012. PMID: 22820247

7

Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides.

Stokes SS, Albert R, Buurman ET, Andrews B, Shapiro AB, Green OM, McKenzie AR, Otterbein LR. Stokes SS, et al. Among authors: shapiro ab. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7019-23. doi: 10.1016/j.bmcl.2012.10.003. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23099094

8

A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα.

Shapiro AB. Shapiro AB. Biochem Pharmacol. 2013 May 1;85(9):1269-77. doi: 10.1016/j.bcp.2013.02.006. Epub 2013 Feb 13. Biochem Pharmacol. 2013. PMID: 23415903

9

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Buurman ET, Foulk MA, Gao N, Laganas VA, McKinney DC, Moustakas DT, Rose JA, Shapiro AB, Fleming PR. Buurman ET, et al. Among authors: shapiro ab. J Bacteriol. 2012 Oct;194(20):5504-12. doi: 10.1128/JB.01103-12. Epub 2012 Jul 27. J Bacteriol. 2012. PMID: 22843845 Free PMC article.

10

Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.

McKinney DC, Eyermann CJ, Gu RF, Hu J, Kazmirski SL, Lahiri SD, McKenzie AR, Shapiro AB, Breault G. McKinney DC, et al. Among authors: shapiro ab. ACS Infect Dis. 2016 Jul 8;2(7):456-64. doi: 10.1021/acsinfecdis.6b00053. Epub 2016 May 9. ACS Infect Dis. 2016. PMID: 27626097

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