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Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.
Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC. Matt T, et al. Among authors: shcherbakov d. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10984-9. doi: 10.1073/pnas.1204073109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699498 Free PMC article.
4'-O-substitutions determine selectivity of aminoglycoside antibiotics.
Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC. Perez-Fernandez D, et al. Among authors: shcherbakov d. Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112. Nat Commun. 2014. PMID: 24473108 Free PMC article.
Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis.
Shcherbakov D, Teo Y, Boukari H, Cortes-Sanchon A, Mantovani M, Osinnii I, Moore J, Juskeviciene R, Brilkova M, Duscha S, Kumar HS, Laczko E, Rehrauer H, Westhof E, Akbergenov R, Böttger EC. Shcherbakov D, et al. Commun Biol. 2019 Oct 17;2:381. doi: 10.1038/s42003-019-0626-9. eCollection 2019. Commun Biol. 2019. PMID: 31637312 Free PMC article.
190 results