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Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Li X, et al. Among authors: li h. J Allergy Clin Immunol. 2012 Oct;130(4):861-8.e7. doi: 10.1016/j.jaci.2012.04.041. Epub 2012 Jun 12. J Allergy Clin Immunol. 2012. PMID: 22694930 Free PMC article.
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.
Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Moore WC, et al. Among authors: li h, li x. Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23. doi: 10.1164/rccm.200906-0896OC. Epub 2009 Nov 5. Am J Respir Crit Care Med. 2010. PMID: 19892860 Free PMC article.
Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.
Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER; National Heart, Lung, and Blood Institute Severe Asthma Research Program. Hastie AT, et al. Among authors: li h. J Allergy Clin Immunol. 2010 May;125(5):1028-1036.e13. doi: 10.1016/j.jaci.2010.02.008. Epub 2010 Apr 15. J Allergy Clin Immunol. 2010. PMID: 20398920 Free PMC article.
Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program.
Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, Gaston BM, Bleecker ER, Moore WC; National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Fitzpatrick AM, et al. Among authors: li x, li h. J Allergy Clin Immunol. 2011 Feb;127(2):382-389.e1-13. doi: 10.1016/j.jaci.2010.11.015. Epub 2010 Dec 31. J Allergy Clin Immunol. 2011. PMID: 21195471 Free PMC article.
Importance of hedgehog interacting protein and other lung function genes in asthma.
Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Peters SP, Hawkins GA, Bleecker ER, Meyers DA. Li X, et al. Among authors: li h. J Allergy Clin Immunol. 2011 Jun;127(6):1457-65. doi: 10.1016/j.jaci.2011.01.056. Epub 2011 Mar 12. J Allergy Clin Immunol. 2011. PMID: 21397937 Free PMC article.
The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients.
Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Li X, et al. Among authors: li h. J Allergy Clin Immunol. 2012 Feb;129(2):575-8, 578.e1-9. doi: 10.1016/j.jaci.2011.09.040. Epub 2011 Nov 8. J Allergy Clin Immunol. 2012. PMID: 22070912 Free PMC article. No abstract available.
The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.
Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute–sponsored Severe Asthma Research Program (SARP). Hawkins GA, et al. Among authors: li x, li h. J Allergy Clin Immunol. 2012 Aug;130(2):510-5.e1. doi: 10.1016/j.jaci.2012.03.018. Epub 2012 May 1. J Allergy Clin Immunol. 2012. PMID: 22554704 Free PMC article.
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Li X, et al. Among authors: li h. J Allergy Clin Immunol. 2013 Aug;132(2):313-20.e15. doi: 10.1016/j.jaci.2013.01.051. Epub 2013 Mar 28. J Allergy Clin Immunol. 2013. PMID: 23541324 Free PMC article.
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects.
Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Hastie AT, et al. Among authors: li h. J Allergy Clin Immunol. 2013 Jul;132(1):72-80. doi: 10.1016/j.jaci.2013.03.044. Epub 2013 May 21. J Allergy Clin Immunol. 2013. PMID: 23706399 Free PMC article.
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