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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.
Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. Fendt SM, et al. Among authors: stephanopoulos g. Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17. Cancer Res. 2013. PMID: 23687346 Free PMC article.
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Lunt SY, et al. Among authors: stephanopoulos g. Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4. Mol Cell. 2015. PMID: 25482511 Free PMC article.
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. Buescher JM, et al. Among authors: stephanopoulos g. Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Curr Opin Biotechnol. 2015. PMID: 25731751 Free PMC article. Review.
Metabolic requirements for cancer cell proliferation.
Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Keibler MA, et al. Among authors: stephanopoulos g. Cancer Metab. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6. eCollection 2016. Cancer Metab. 2016. PMID: 27540483 Free PMC article.
Metabolic pathway alterations that support cell proliferation.
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Vander Heiden MG, et al. Among authors: stephanopoulos g. Cold Spring Harb Symp Quant Biol. 2011;76:325-34. doi: 10.1101/sqb.2012.76.010900. Epub 2012 Jan 19. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22262476 Review.
Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G. Keibler MA, et al. Among authors: stephanopoulos g. FEBS J. 2021 Oct;288(19):5629-5649. doi: 10.1111/febs.15858. Epub 2021 May 13. FEBS J. 2021. PMID: 33811729 Free PMC article.
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Locasale JW, et al. Among authors: stephanopoulos g. Nat Genet. 2011 Jul 31;43(9):869-74. doi: 10.1038/ng.890. Nat Genet. 2011. PMID: 21804546 Free PMC article.
375 results