Läer S - Search Results

1

Physiologically based pharmacokinetic (PBPK) modeling in children.

Barrett JS, Della Casa Alberighi O, Läer S, Meibohm B. Barrett JS, et al. Among authors: laer s. Clin Pharmacol Ther. 2012 Jul;92(1):40-9. doi: 10.1038/clpt.2012.64. Epub 2012 Jun 6. Clin Pharmacol Ther. 2012. PMID: 22669290 Review.

2

The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy.

Läer S, Barrett JS, Meibohm B. Läer S, et al. J Clin Pharmacol. 2009 Aug;49(8):889-904. doi: 10.1177/0091270009337513. Epub 2009 Jun 16. J Clin Pharmacol. 2009. PMID: 19531673 Review.

3

Response to "Physiologically based pharmacokinetic modeling at the extremes of age".

Della Casa Alberighi O, Barrett JS, Läer S, Meibohm B. Della Casa Alberighi O, et al. Among authors: laer s. Clin Pharmacol Ther. 2013 Feb;93(2):149. doi: 10.1038/clpt.2012.200. Epub 2012 Nov 28. Clin Pharmacol Ther. 2013. PMID: 23187875 No abstract available.

4

Population pharmacokinetic studies in pediatrics: issues in design and analysis.

Meibohm B, Läer S, Panetta JC, Barrett JS. Meibohm B, et al. Among authors: laer s. AAPS J. 2005 Oct 5;7(2):E475-87. doi: 10.1208/aapsj070248. AAPS J. 2005. PMID: 16353925 Free PMC article. Review.

5

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.

Albers S, Meibohm B, Mir TS, Läer S. Albers S, et al. Among authors: laer s. Br J Clin Pharmacol. 2008 Apr;65(4):511-22. doi: 10.1111/j.1365-2125.2007.03046.x. Epub 2007 Nov 8. Br J Clin Pharmacol. 2008. PMID: 17995971 Free PMC article. Clinical Trial.

6

Study design and simulation approach.

Läer S, Meibohm B. Läer S, et al. Handb Exp Pharmacol. 2011;205:125-48. doi: 10.1007/978-3-642-20195-0_6. Handb Exp Pharmacol. 2011. PMID: 21882109

7

Development of a safe and effective pediatric dosing regimen for sotalol based on population pharmacokinetics and pharmacodynamics in children with supraventricular tachycardia.

Läer S, Elshoff JP, Meibohm B, Weil J, Mir TS, Zhang W, Hulpke-Wette M. Läer S, et al. J Am Coll Cardiol. 2005 Oct 4;46(7):1322-30. doi: 10.1016/j.jacc.2005.06.061. J Am Coll Cardiol. 2005. PMID: 16198851 Free article.

8

Termination of automatic atrial tachycardia in an infant by adequate sotalol dosing. Indication of clinically relevant age-dependent pharmacokinetics of sotalol.

Läer S, Meibohm B, Mir TS, Hulpke-Wette M. Läer S, et al. Eur J Clin Pharmacol. 2001 May;57(2):181-2. doi: 10.1007/s002280100294. Eur J Clin Pharmacol. 2001. PMID: 11417452 No abstract available.

9

Pharmacokinetics of intravenous amiodarone in children.

Ramusovic S, Läer S, Meibohm B, Lagler FB, Paul T. Ramusovic S, et al. Among authors: laer s. Arch Dis Child. 2013 Dec;98(12):989-93. doi: 10.1136/archdischild-2013-304483. Epub 2013 Sep 19. Arch Dis Child. 2013. PMID: 24051016

10

Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.

Khalil F, Läer S. Khalil F, et al. Among authors: laer s. J Biomed Biotechnol. 2011;2011:907461. doi: 10.1155/2011/907461. Epub 2011 Jun 1. J Biomed Biotechnol. 2011. PMID: 21716673 Free PMC article. Review.

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