Chandel NS - Search Results

1

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.

Jeon SM, Chandel NS, Hay N. Jeon SM, et al. Among authors: chandel ns. Nature. 2012 May 9;485(7400):661-5. doi: 10.1038/nature11066. Nature. 2012. PMID: 22660331 Free PMC article.

2

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death.

McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N, Chandel NS. McClintock DS, et al. Among authors: chandel ns. Mol Cell Biol. 2002 Jan;22(1):94-104. doi: 10.1128/MCB.22.1.94-104.2002. Mol Cell Biol. 2002. PMID: 11739725 Free PMC article.

3

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS. Brunelle JK, et al. Among authors: chandel ns. J Biol Chem. 2004 Feb 6;279(6):4305-12. doi: 10.1074/jbc.M312241200. Epub 2003 Nov 19. J Biol Chem. 2004. PMID: 14627695 Free article.

4

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.

Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. Majewski N, et al. Among authors: chandel ns. Mol Cell. 2004 Dec 3;16(5):819-30. doi: 10.1016/j.molcel.2004.11.014. Mol Cell. 2004. PMID: 15574336 Free article.

5

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS. Emerling BM, et al. Among authors: chandel ns. Free Radic Biol Med. 2009 May 15;46(10):1386-91. doi: 10.1016/j.freeradbiomed.2009.02.019. Epub 2009 Mar 3. Free Radic Biol Med. 2009. PMID: 19268526 Free PMC article.

6

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.

Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N. Patra KC, et al. Cancer Cell. 2013 Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Cancer Cell. 2013. PMID: 23911236 Free PMC article.

7

Targeting mitochondria metabolism for cancer therapy.

Weinberg SE, Chandel NS. Weinberg SE, et al. Among authors: chandel ns. Nat Chem Biol. 2015 Jan;11(1):9-15. doi: 10.1038/nchembio.1712. Nat Chem Biol. 2015. PMID: 25517383 Free PMC article. Review.

8

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Chandel NS, Jasper H, Ho TT, Passegué E. Chandel NS, et al. Nat Cell Biol. 2016 Aug;18(8):823-32. doi: 10.1038/ncb3385. Epub 2016 Jul 18. Nat Cell Biol. 2016. PMID: 27428307 Review.

9

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. Reczek CR, et al. Among authors: chandel ns. Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499. Epub 2017 Oct 23. Nat Chem Biol. 2017. PMID: 29058724 Free PMC article.

10

Hexokinase 2 is dispensable for T cell-dependent immunity.

Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS. Mehta MM, et al. Among authors: chandel ns. Cancer Metab. 2018 Aug 17;6:10. doi: 10.1186/s40170-018-0184-5. eCollection 2018. Cancer Metab. 2018. PMID: 30140438 Free PMC article.

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