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Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice.
Chopra N, Kannankeril PJ, Yang T, Hlaing T, Holinstat I, Ettensohn K, Pfeifer K, Akin B, Jones LR, Franzini-Armstrong C, Knollmann BC. Chopra N, et al. Among authors: knollmann bc. Circ Res. 2007 Sep 14;101(6):617-26. doi: 10.1161/CIRCRESAHA.107.157552. Epub 2007 Jul 26. Circ Res. 2007. PMID: 17656677
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias.
Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Chopra N, et al. Among authors: knollmann bc, knollmann ritschel be. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7636-41. doi: 10.1073/pnas.0902919106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383796 Free PMC article.
187 results