Obach RS - Search Results

1

A novel relay method for determining low-clearance values.

Di L, Trapa P, Obach RS, Atkinson K, Bi YA, Wolford AC, Tan B, McDonald TS, Lai Y, Tremaine LM. Di L, et al. Among authors: obach rs. Drug Metab Dispos. 2012 Sep;40(9):1860-5. doi: 10.1124/dmd.112.046425. Epub 2012 May 29. Drug Metab Dispos. 2012. PMID: 22645091

2

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

Obach RS. Obach RS. Drug Metab Dispos. 1997 Dec;25(12):1359-69. Drug Metab Dispos. 1997. PMID: 9394025

3

Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine.

Obach RS, Pablo J, Mash DC. Obach RS, et al. Drug Metab Dispos. 1998 Aug;26(8):764-8. Drug Metab Dispos. 1998. PMID: 9698290

4

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

Obach RS. Obach RS. Drug Metab Dispos. 1999 Nov;27(11):1350-9. Drug Metab Dispos. 1999. PMID: 10534321

5

Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.

Obach RS. Obach RS. Drug Metab Dispos. 2000 Sep;28(9):1069-76. Drug Metab Dispos. 2000. PMID: 10950851

6

(R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes.

Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS. Margolis JM, et al. Among authors: obach rs. Drug Metab Dispos. 2000 Oct;28(10):1187-91. Drug Metab Dispos. 2000. PMID: 10997938

7

Metabolic characterization of the major human small intestinal cytochrome p450s.

Obach RS, Zhang QY, Dunbar D, Kaminsky LS. Obach RS, et al. Drug Metab Dispos. 2001 Mar;29(3):347-52. Drug Metab Dispos. 2001. PMID: 11181505

8

Cytochrome P450-catalyzed metabolism of ezlopitant alkene (CJ-12,458), a pharmacologically active metabolite of ezlopitant: enzyme kinetics and mechanism of an alkene hydration reaction.

Obach RS. Obach RS. Drug Metab Dispos. 2001 Jul;29(7):1057-67. Drug Metab Dispos. 2001. PMID: 11408374

9

Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs.

Obach RS. Obach RS. Drug Metab Dispos. 2001 Dec;29(12):1599-607. Drug Metab Dispos. 2001. PMID: 11717179

10

The prediction of human clearance from hepatic microsomal metabolism data.

Obach RS. Obach RS. Curr Opin Drug Discov Devel. 2001 Jan;4(1):36-44. Curr Opin Drug Discov Devel. 2001. PMID: 11727321 Review.

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