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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Safina BS, Baker S, Baumgardner M, Blaney PM, Chan BK, Chen YH, Cartwright MW, Castanedo G, Chabot C, Cheguillaume AJ, Goldsmith P, Goldstein DM, Goyal B, Hancox T, Handa RK, Iyer PS, Kaur J, Kondru R, Kenny JR, Krintel SL, Li J, Lesnick J, Lucas MC, Lewis C, Mukadam S, Murray J, Nadin AJ, Nonomiya J, Padilla F, Palmer WS, Pang J, Pegg N, Price S, Reif K, Salphati L, Savy PA, Seward EM, Shuttleworth S, Sohal S, Sweeney ZK, Tay S, Tivitmahaisoon P, Waszkowycz B, Wei B, Yue Q, Zhang C, Sutherlin DP. Safina BS, et al. Among authors: handa rk. J Med Chem. 2012 Jun 28;55(12):5887-900. doi: 10.1021/jm3003747. Epub 2012 Jun 11. J Med Chem. 2012. PMID: 22626259
Alternative modes of binding of proteins with tandem SH2 domains.
O'Brien R, Rugman P, Renzoni D, Layton M, Handa R, Hilyard K, Waterfield MD, Driscoll PC, Ladbury JE. O'Brien R, et al. Protein Sci. 2000 Mar;9(3):570-9. doi: 10.1110/ps.9.3.570. Protein Sci. 2000. PMID: 10752619 Free PMC article.
In Vivo Renal Tubule pH in Stone-Forming Human Kidneys.
Borofsky MS, Handa RK, Evan AP, Williams JC Jr, Bledsoe S, Coe FL, Worcester EM, Lingeman JE. Borofsky MS, et al. Among authors: handa rk. J Endourol. 2020 Feb;34(2):203-208. doi: 10.1089/end.2019.0378. J Endourol. 2020. PMID: 31760802 Free PMC article.
73 results