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A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens R. Tong G, et al. Among authors: wong o. Br J Clin Pharmacol. 2013 Jan;75(1):136-45. doi: 10.1111/j.1365-2125.2012.04339.x. Br J Clin Pharmacol. 2013. PMID: 22616739 Free PMC article.
Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers.
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC. Tong G, et al. Among authors: wong o. Clin Ther. 2012 Mar;34(3):654-67. doi: 10.1016/j.clinthera.2012.01.022. Epub 2012 Feb 28. Clin Ther. 2012. PMID: 22381714 Clinical Trial.
A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects.
Dockens R, Wang JS, Castaneda L, Sverdlov O, Huang SP, Slemmon R, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Tong G. Dockens R, et al. Among authors: wong o. Clin Pharmacokinet. 2012 Oct 1;51(10):681-93. doi: 10.1007/s40262-012-0005-x. Clin Pharmacokinet. 2012. PMID: 23018531 Clinical Trial.
Electrochemiluminescence in bioanalysis.
Rhyne PW, Wong OT, Zhang YJ, Weiner RS. Rhyne PW, et al. Bioanalysis. 2009 Aug;1(5):919-35. doi: 10.4155/bio.09.80. Bioanalysis. 2009. PMID: 21083063 Review.
427 results