Barz D - Search Results

1

Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).

Banoglu E, Çalişkan B, Luderer S, Eren G, Özkan Y, Altenhofen W, Weinigel C, Barz D, Gerstmeier J, Pergola C, Werz O. Banoglu E, et al. Among authors: barz d. Bioorg Med Chem. 2012 Jun 15;20(12):3728-41. doi: 10.1016/j.bmc.2012.04.048. Epub 2012 May 1. Bioorg Med Chem. 2012. PMID: 22607880

2

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

Pergola C, Gaboriaud-Kolar N, Jestädt N, König S, Kritsanida M, Schaible AM, Li H, Garscha U, Weinigel C, Barz D, Albring KF, Huber O, Skaltsounis AL, Werz O. Pergola C, et al. Among authors: barz d. J Med Chem. 2014 May 8;57(9):3715-23. doi: 10.1021/jm401740w. Epub 2014 Apr 17. J Med Chem. 2014. PMID: 24697244

3

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis.

Gerstmeier J, Weinigel C, Barz D, Werz O, Garscha U. Gerstmeier J, et al. Among authors: barz d. Biochim Biophys Acta. 2014 Sep;1840(9):2961-9. doi: 10.1016/j.bbagen.2014.05.016. Epub 2014 Jun 4. Biochim Biophys Acta. 2014. PMID: 24905297

4

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, Collado JA, Werz O. Koeberle A, et al. Among authors: barz d. J Med Chem. 2014 Jul 10;57(13):5638-48. doi: 10.1021/jm500308c. Epub 2014 Jun 24. J Med Chem. 2014. PMID: 24920381

5

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).

Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O. Pergola C, et al. Among authors: barz d. Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625. Br J Pharmacol. 2014. PMID: 24641614 Free PMC article.

6

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O. Hanke T, et al. Among authors: barz d. J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24171493

7

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes.

Pergola C, Rogge A, Dodt G, Northoff H, Weinigel C, Barz D, Rådmark O, Sautebin L, Werz O. Pergola C, et al. Among authors: barz d. FASEB J. 2011 Oct;25(10):3377-87. doi: 10.1096/fj.11-182758. Epub 2011 Jun 21. FASEB J. 2011. PMID: 21693622

8

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

Chini MG, De Simone R, Bruno I, Riccio R, Dehm F, Weinigel C, Barz D, Werz O, Bifulco G. Chini MG, et al. Among authors: barz d. Eur J Med Chem. 2012 Aug;54:311-23. doi: 10.1016/j.ejmech.2012.05.014. Epub 2012 May 18. Eur J Med Chem. 2012. PMID: 22683242

9

Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.

Peduto A, Bruno F, Dehm F, Krauth V, de Caprariis P, Weinigel C, Barz D, Massa A, De Rosa M, Werz O, Filosa R. Peduto A, et al. Among authors: barz d. Eur J Med Chem. 2014 Jun 23;81:492-8. doi: 10.1016/j.ejmech.2014.05.033. Epub 2014 May 14. Eur J Med Chem. 2014. PMID: 24871899

10

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.

Filosa R, Peduto A, Schaible AM, Krauth V, Weinigel C, Barz D, Petronzi C, Bruno F, Roviezzo F, Spaziano G, D'Agostino B, De Rosa M, Werz O. Filosa R, et al. Among authors: barz d, d agostino b. Eur J Med Chem. 2015 Apr 13;94:132-9. doi: 10.1016/j.ejmech.2015.02.042. Epub 2015 Feb 24. Eur J Med Chem. 2015. PMID: 25765759

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