Brents LK - Search Results

1

Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.

Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Safe SH, et al. Among authors: brents lk. Anticancer Agents Med Chem. 2012 Dec;12(10):1211-20. doi: 10.2174/187152012803833099. Anticancer Agents Med Chem. 2012. PMID: 22583404 Free PMC article. Review.

2

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.

Brents LK, Reichard EE, Zimmerman SM, Moran JH, Fantegrossi WE, Prather PL. Brents LK, et al. PLoS One. 2011;6(7):e21917. doi: 10.1371/journal.pone.0021917. Epub 2011 Jul 6. PLoS One. 2011. PMID: 21755008 Free PMC article.

3

Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.

Brents LK, Medina-Bolivar F, Seely KA, Nair V, Bratton SM, Nopo-Olazabal L, Patel RY, Liu H, Doerksen RJ, Prather PL, Radominska-Pandya A. Brents LK, et al. Xenobiotica. 2012 Feb;42(2):139-56. doi: 10.3109/00498254.2011.609570. Epub 2011 Oct 4. Xenobiotica. 2012. PMID: 21970716 Free PMC article.

4

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.

Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL. Brents LK, et al. Biochem Pharmacol. 2012 Apr 1;83(7):952-61. doi: 10.1016/j.bcp.2012.01.004. Epub 2012 Jan 18. Biochem Pharmacol. 2012. PMID: 22266354 Free PMC article.

5

A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors.

Seely KA, Brents LK, Radominska-Pandya A, Endres GW, Keyes GS, Moran JH, Prather PL. Seely KA, et al. Among authors: brents lk. Chem Res Toxicol. 2012 Apr 16;25(4):825-7. doi: 10.1021/tx3000472. Epub 2012 Mar 15. Chem Res Toxicol. 2012. PMID: 22404317 Free PMC article.

6

Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.

Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S. Liu X, et al. Among authors: brents lk. Mol Cancer Ther. 2012 Jul;11(7):1421-31. doi: 10.1158/1535-7163.MCT-12-0026. Epub 2012 May 2. Mol Cancer Ther. 2012. PMID: 22553354 Free PMC article.

7

AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.

Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL. Seely KA, et al. Among authors: brents lk. Neuropharmacology. 2012 Oct;63(5):905-15. doi: 10.1016/j.neuropharm.2012.06.046. Epub 2012 Jul 4. Neuropharmacology. 2012. PMID: 22771770 Free PMC article.

8

Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH. Chimalakonda KC, et al. Among authors: brents lk. Drug Metab Dispos. 2012 Nov;40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17. Drug Metab Dispos. 2012. PMID: 22904561 Free PMC article.

9

Effects of the β-agonist, isoprenaline, on the down-regulation, functional responsiveness and trafficking of β2-adrenergic receptors with N-terminal polymorphisms.

Koryakina Y, Jones SM, Cornett LE, Seely K, Brents L, Prather PL, Kofman A, Kurten RC. Koryakina Y, et al. Cell Biol Int. 2012;36(12):1171-83. doi: 10.1042/CBI20120134. Cell Biol Int. 2012. PMID: 22938397 Free PMC article.

10

Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.

Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Madadi NR, et al. Among authors: brents lk. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2019-21. doi: 10.1016/j.bmcl.2013.02.025. Epub 2013 Feb 14. Bioorg Med Chem Lett. 2013. PMID: 23466226 Free PMC article.

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