Wirz B - Search Results

1

Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro.

Gschwind HP, Glaenzel U, Waldmeier F, Wirz B, Sabia HD, Picard F, Weiss HM, Choi L, Swart PJ, Vasudevan A, Azria M. Gschwind HP, et al. Among authors: wirz b. Eur J Pharm Sci. 2012 Aug 30;47(1):44-55. doi: 10.1016/j.ejps.2012.04.023. Epub 2012 May 8. Eur J Pharm Sci. 2012. PMID: 22579664

2

Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers.

Waldmeier F, Glaenzel U, Wirz B, Oberer L, Schmid D, Seiberling M, Valencia J, Riviere GJ, End P, Vaidyanathan S. Waldmeier F, et al. Among authors: wirz b. Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797. Epub 2007 May 17. Drug Metab Dispos. 2007. PMID: 17510248 Clinical Trial.

3

ADME investigations of unnatural peptides: distribution of a 14C-labeled beta 3-octaarginine in rats.

Weiss HM, Wirz B, Schweitzer A, Amstutz R, Rodriguez Perez MI, Andres H, Metz Y, Gardiner J, Seebach D. Weiss HM, et al. Among authors: wirz b. Chem Biodivers. 2007 Jul;4(7):1413-37. doi: 10.1002/cbdv.200790121. Chem Biodivers. 2007. PMID: 17638323

4

The outstanding metabolic stability of a 14C-labeled beta-nonapeptide in rats--in vitro and in vivo pharmacokinetic studies.

Wiegand H, Wirz B, Schweitzer A, Camenisch GP, Rodriguez Perez MI, Gross G, Woessner R, Voges R, Arvidsson PI, Frackenpohl J, Seebach D. Wiegand H, et al. Among authors: wirz b. Biopharm Drug Dispos. 2002 Sep;23(6):251-62. doi: 10.1002/bdd.334. Biopharm Drug Dispos. 2002. PMID: 12214326

5

Pharmacokinetic investigation of a 14C-labelled beta 3/alpha tetrapeptide in rats.

Wiegand H, Wirz B, Schweitzer A, Gross G, Perez MI, Andres H, Kimmerlin T, Rueping M, Seebach D. Wiegand H, et al. Among authors: wirz b. Chem Biodivers. 2004 Nov;1(11):1812-28. doi: 10.1002/cbdv.200490136. Chem Biodivers. 2004. PMID: 17191818

6

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib.

Han C, Savage S, Al-Sayah M, Yajima H, Remarchuk T, Reents R, Wirz B, Iding H, Bachmann S, Fantasia SM, Scalone M, Hell A, Hidber P, Gosselin F. Han C, et al. Among authors: wirz b. Org Lett. 2017 Sep 15;19(18):4806-4809. doi: 10.1021/acs.orglett.7b02228. Epub 2017 Aug 31. Org Lett. 2017. PMID: 28858516

7

Extended Catalytic Scope of a Well-Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase.

Roth S, Präg A, Wechsler C, Marolt M, Ferlaino S, Lüdeke S, Sandon N, Wetzl D, Iding H, Wirz B, Müller M. Roth S, et al. Among authors: wirz b. Chembiochem. 2017 Sep 5;18(17):1703-1706. doi: 10.1002/cbic.201700261. Epub 2017 Jul 19. Chembiochem. 2017. PMID: 28722796

8

Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Weiß MS, et al. Among authors: wirz b. Chembiochem. 2017 Jun 1;18(11):1022-1026. doi: 10.1002/cbic.201700033. Epub 2017 Apr 27. Chembiochem. 2017. PMID: 28334484

9

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Weiß MS, et al. Among authors: wirz b. Org Biomol Chem. 2016 Nov 2;14(43):10249-10254. doi: 10.1039/c6ob02139e. Org Biomol Chem. 2016. PMID: 27739550

10

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines.

Pavlidis IV, Weiß MS, Genz M, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT. Pavlidis IV, et al. Among authors: wirz b. Nat Chem. 2016 Nov;8(11):1076-1082. doi: 10.1038/nchem.2578. Epub 2016 Jul 18. Nat Chem. 2016. PMID: 27768108

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