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Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.
Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB. Castaño Betancourt MC, et al. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566624 Free PMC article.
Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.
Evans DS, Cailotto F, Parimi N, Valdes AM, Castaño-Betancourt MC, Liu Y, Kaplan RC, Bidlingmaier M, Vasan RS, Teumer A, Tranah GJ, Nevitt MC, Cummings SR, Orwoll ES, Barrett-Connor E, Renner JB, Jordan JM, Doherty M, Doherty SA, Uitterlinden AG, van Meurs JB, Spector TD, Lories RJ, Lane NE. Evans DS, et al. Among authors: castano betancourt mc. Ann Rheum Dis. 2015 Oct;74(10):1861-7. doi: 10.1136/annrheumdis-2013-205020. Epub 2014 Jun 13. Ann Rheum Dis. 2015. PMID: 24928840 Free PMC article.
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.
Castaño-Betancourt MC, Evans DS, Ramos YF, Boer CG, Metrustry S, Liu Y, den Hollander W, van Rooij J, Kraus VB, Yau MS, Mitchell BD, Muir K, Hofman A, Doherty M, Doherty S, Zhang W, Kraaij R, Rivadeneira F, Barrett-Connor E, Maciewicz RA, Arden N, Nelissen RG, Kloppenburg M, Jordan JM, Nevitt MC, Slagboom EP, Hart DJ, Lafeber F, Styrkarsdottir U, Zeggini E, Evangelou E, Spector TD, Uitterlinden AG, Lane NE, Meulenbelt I, Valdes AM, van Meurs JB. Castaño-Betancourt MC, et al. PLoS Genet. 2016 Oct 4;12(10):e1006260. doi: 10.1371/journal.pgen.1006260. eCollection 2016 Oct. PLoS Genet. 2016. PMID: 27701424 Free PMC article.
The contribution of hip geometry to the prediction of hip osteoarthritis.
Castaño-Betancourt MC, Van Meurs JB, Bierma-Zeinstra S, Rivadeneira F, Hofman A, Weinans H, Uitterlinden AG, Waarsing JH. Castaño-Betancourt MC, et al. Osteoarthritis Cartilage. 2013 Oct;21(10):1530-6. doi: 10.1016/j.joca.2013.06.012. Epub 2013 Jun 27. Osteoarthritis Cartilage. 2013. PMID: 23811490 Free article.
Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index.
Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, de Maat MP, Hofman A, Pols HA, Rivadeneira F, Witteman JC, Uitterlinden AG, van Meurs JB. Kerkhof HJ, et al. Among authors: castano betancourt mc. Ann Rheum Dis. 2010 Nov;69(11):1976-82. doi: 10.1136/ard.2009.125260. Epub 2010 May 28. Ann Rheum Dis. 2010. PMID: 20511616 Review.
The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.
Evangelou E, Valdes AM, Castano-Betancourt MC, Doherty M, Doherty S, Esko T, Ingvarsson T, Ioannidis JP, Kloppenburg M, Metspalu A, Ntzani EE, Panoutsopoulou K, Slagboom PE, Southam L, Spector TD, Styrkarsdottir U, Stefanson K, Uitterlinden AG, Wheeler M, Zeggini E, Meulenbelt I, van Meurs JB; arcOGEN consortium, the TREAT-OA consortium. Evangelou E, et al. Among authors: castano betancourt mc. Ann Rheum Dis. 2013 Jul;72(7):1264-5. doi: 10.1136/annrheumdis-2012-203182. Epub 2013 Mar 16. Ann Rheum Dis. 2013. PMID: 23505243 Free PMC article. No abstract available.
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, Mellström D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulch… See abstract for full author list ➔ Estrada K, et al. Among authors: castano betancourt m. Nat Genet. 2012 Apr 15;44(5):491-501. doi: 10.1038/ng.2249. Nat Genet. 2012. PMID: 22504420 Free PMC article.
22 results