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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. Price NL, et al. Among authors: moaddel r. Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003. Cell Metab. 2012. PMID: 22560220 Free PMC article.
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Jimenez-Gomez Y, et al. Among authors: moaddel r. Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004. Cell Metab. 2013. PMID: 24093677 Free PMC article.
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA. Scheibye-Knudsen M, et al. Among authors: moaddel r. Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4. Cell Metab. 2014. PMID: 25440059 Free PMC article.
Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
Bernier M, Wahl D, Ali A, Allard J, Faulkner S, Wnorowski A, Sanghvi M, Moaddel R, Alfaras I, Mattison JA, Tarantini S, Tucsek Z, Ungvari Z, Csiszar A, Pearson KJ, de Cabo R. Bernier M, et al. Among authors: moaddel r. Aging (Albany NY). 2016 May;8(5):899-916. doi: 10.18632/aging.100942. Aging (Albany NY). 2016. PMID: 27070252 Free PMC article.
Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.
Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, Crandall JP. Pollack RM, et al. Among authors: moaddel r. J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1703-1709. doi: 10.1093/gerona/glx041. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329397 Free PMC article. Clinical Trial.
Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.
Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R. Mercken EM, et al. Among authors: moaddel r. NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017. NPJ Aging Mech Dis. 2017. PMID: 28649426 Free PMC article.
Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging.
Semba RD, Zhang P, Adelnia F, Sun K, Gonzalez-Freire M, Salem N Jr, Brennan N, Spencer RG, Fishbein K, Khadeer M, Shardell M, Moaddel R, Ferrucci L. Semba RD, et al. Among authors: moaddel r. Aging Cell. 2019 Apr;18(2):e12915. doi: 10.1111/acel.12915. Epub 2019 Feb 4. Aging Cell. 2019. PMID: 30719830 Free PMC article.
226 results