Prakash C - Search Results

1

Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol S-methyltransferase in humans: an in vitro study.

Obach RS, Prakash C, Kamel AM. Obach RS, et al. Among authors: prakash c. Xenobiotica. 2012 Nov;42(11):1049-57. doi: 10.3109/00498254.2012.683203. Epub 2012 May 4. Xenobiotica. 2012. PMID: 22559212

2

Characterization of a novel metabolite intermediate of ziprasidone in hepatic cytosolic fractions of rat, dog, and human by ESI-MS/MS, hydrogen/deuterium exchange, and chemical derivatization.

Miao Z, Kamel A, Prakash C. Miao Z, et al. Among authors: prakash c. Drug Metab Dispos. 2005 Jul;33(7):879-83. doi: 10.1124/dmd.105.004036. Epub 2005 Apr 8. Drug Metab Dispos. 2005. PMID: 15821046

3

Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans.

Prakash C, Kamel A, Gummerus J, Wilner K. Prakash C, et al. Drug Metab Dispos. 1997 Jul;25(7):863-72. Drug Metab Dispos. 1997. PMID: 9224781 Clinical Trial.

4

Characterization of the novel benzisothiazole ring-cleaved products of the antipsychotic drug ziprasidone.

Prakash C, Kamel A, Cui D. Prakash C, et al. Drug Metab Dispos. 1997 Jul;25(7):897-901. Drug Metab Dispos. 1997. PMID: 9224786

5

Metabolism, pharmacokinetics and excretion of a potent tachykinin NK1 receptor antagonist (CP-122,721) in rat: characterization of a novel oxidative pathway.

Kamel A, Davis J, Potchoiba MJ, Prakash C. Kamel A, et al. Among authors: prakash c. Xenobiotica. 2006 Feb-Mar;36(2-3):235-58. doi: 10.1080/00498250600594444. Xenobiotica. 2006. PMID: 16702114

6

Metabolism and excretion of the novel antipsychotic drug ziprasidone in rats after oral administration of a mixture of 14C- and 3H-labeled ziprasidone.

Prakash C, Kamel A, Anderson W, Howard H. Prakash C, et al. Drug Metab Dispos. 1997 Feb;25(2):206-18. Drug Metab Dispos. 1997. PMID: 9029052

7

Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.

Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D. Prakash C, et al. Br J Clin Pharmacol. 2000;49 Suppl 1(Suppl 1):35S-42S. doi: 10.1046/j.1365-2125.2000.00151.x. Br J Clin Pharmacol. 2000. PMID: 10771452 Free PMC article.

8

Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma.

Kamel A, Du Y, Colizza K, Prakash C. Kamel A, et al. Among authors: prakash c. Xenobiotica. 2007 May;37(5):559-78. doi: 10.1080/00498250701278434. Xenobiotica. 2007. PMID: 17523057

9

High performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometry (HPLC/API/MS/MS) in drug metabolism and toxicology.

Kamel A, Prakash C. Kamel A, et al. Among authors: prakash c. Curr Drug Metab. 2006 Dec;7(8):837-52. doi: 10.2174/138920006779010593. Curr Drug Metab. 2006. PMID: 17168686 Review.

10

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: prakash c. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

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