Simeonov A - Search Results

1

Differential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferase.

Lea WA, Simeonov A. Lea WA, et al. Among authors: simeonov a. PLoS One. 2012;7(4):e36219. doi: 10.1371/journal.pone.0036219. Epub 2012 Apr 30. PLoS One. 2012. PMID: 22558390 Free PMC article.

2

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. Lea WA, et al. Among authors: simeonov a. Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149. Assay Drug Dev Technol. 2008. PMID: 18665782 Free PMC article.

3

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: simeonov a. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

4

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.

Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2009 Oct 22;52(20):6474-83. doi: 10.1021/jm901021k. J Med Chem. 2009. PMID: 19761212 Free PMC article.

5

A high-throughput approach for identification of novel general anesthetics.

Lea WA, Xi J, Jadhav A, Lu L, Austin CP, Simeonov A, Eckenhoff RG. Lea WA, et al. Among authors: simeonov a. PLoS One. 2009 Sep 24;4(9):e7150. doi: 10.1371/journal.pone.0007150. PLoS One. 2009. PMID: 19777064 Free PMC article.

6

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity.

Yasgar A, Shultz J, Zhou W, Wang H, Huang F, Murphy N, Abel EL, DiGiovanni J, Inglese J, Simeonov A. Yasgar A, et al. Among authors: simeonov a. Assay Drug Dev Technol. 2010 Apr;8(2):200-11. doi: 10.1089/adt.2009.0248. Assay Drug Dev Technol. 2010. PMID: 20085484 Free PMC article.

7

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: simeonov a. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

8

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Marugan JJ, et al. Among authors: simeonov a. J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20. J Med Chem. 2011. PMID: 21250698 Free PMC article.

9

Literature search and review.

Auld D, Lea W, Davis MI, Simeonov A. Auld D, et al. Among authors: simeonov a. Assay Drug Dev Technol. 2011 Jun;9(3):198-212. doi: 10.1089/adt.2011.0903.lr. Assay Drug Dev Technol. 2011. PMID: 21612549 Review. No abstract available.

10

Fluorescence polarization assays in small molecule screening.

Lea WA, Simeonov A. Lea WA, et al. Among authors: simeonov a. Expert Opin Drug Discov. 2011 Jan;6(1):17-32. doi: 10.1517/17460441.2011.537322. Expert Opin Drug Discov. 2011. PMID: 22328899 Free PMC article.

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