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NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension.
Fiorucci S, Antonelli E, Morelli O, Mencarelli A, Casini A, Mello T, Palazzetti B, Tallet D, del Soldato P, Morelli A. Fiorucci S, et al. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8897-902. doi: 10.1073/pnas.151136298. Epub 2001 Jul 10. Proc Natl Acad Sci U S A. 2001. PMID: 11447266 Free PMC article.
NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines.
Fiorucci S, Distrutti E, Ajuebor MN, Mencarelli A, Mannucci R, Palazzetti B, Del Soldato P, Morelli A, Wallace JL. Fiorucci S, et al. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G654-65. doi: 10.1152/ajpgi.2001.281.3.G654. Am J Physiol Gastrointest Liver Physiol. 2001. Retraction in: Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G860. doi: 10.1152/ajpgi.00000.2009 PMID: 11518677 Free article. Retracted.
A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.
Fiorucci S, Antonelli E, Mencarelli A, Palazzetti B, Alvarez-Miller L, Muscara M, del Soldato P, Sanpaolo L, Wallace JL, Morelli A. Fiorucci S, et al. Br J Pharmacol. 2002 Feb;135(3):589-99. doi: 10.1038/sj.bjp.0704500. Br J Pharmacol. 2002. Retraction in: Br J Pharmacol. 2009 Mar;156(5):868. doi: 10.1111/j.1476-5381.2009.00272.x PMID: 11834606 Free PMC article. Retracted.
411 results