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Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.
Meissner A, Yang J, Kroetsch JT, Sauvé M, Dax H, Momen A, Noyan-Ashraf MH, Heximer S, Husain M, Lidington D, Bolz SS. Meissner A, et al. Among authors: heximer s. Circulation. 2012 Jun 5;125(22):2739-50. doi: 10.1161/CIRCULATIONAHA.111.047316. Epub 2012 Apr 25. Circulation. 2012. PMID: 22534621
The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.
Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. Martino TA, et al. Among authors: heximer s. J Am Coll Cardiol. 2011 May 17;57(20):2020-8. doi: 10.1016/j.jacc.2010.11.022. J Am Coll Cardiol. 2011. PMID: 21565639 Free article.
Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.
Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Rose RA, et al. Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11. Circ Arrhythm Electrophysiol. 2011. PMID: 21747058 Free PMC article.
Metoprolol impairs resistance artery function in mice.
El Beheiry MH, Heximer SP, Voigtlaender-Bolz J, Mazer CD, Connelly KA, Wilson DF, Beattie WS, Tsui AK, Zhang H, Golam K, Hu T, Liu E, Lidington D, Bolz SS, Hare GM. El Beheiry MH, et al. J Appl Physiol (1985). 2011 Oct;111(4):1125-33. doi: 10.1152/japplphysiol.01340.2010. Epub 2011 Jul 28. J Appl Physiol (1985). 2011. PMID: 21799135 Free PMC article.
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Tsui AK, et al. Among authors: heximer sp. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17544-9. doi: 10.1073/pnas.1114026108. Epub 2011 Oct 5. Proc Natl Acad Sci U S A. 2011. PMID: 21976486 Free PMC article.
73 results