Nelson SD - Search Results

1

Interaction of lapatinib with cytochrome P450 3A5.

Chan EC, New LS, Chua TB, Yap CW, Ho HK, Nelson SD. Chan EC, et al. Among authors: nelson sd. Drug Metab Dispos. 2012 Jul;40(7):1414-22. doi: 10.1124/dmd.112.044958. Epub 2012 Apr 17. Drug Metab Dispos. 2012. PMID: 22511346

2

Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib.

Teng WC, Oh JW, New LS, Wahlin MD, Nelson SD, Ho HK, Chan EC. Teng WC, et al. Among authors: nelson sd. Mol Pharmacol. 2010 Oct;78(4):693-703. doi: 10.1124/mol.110.065839. Epub 2010 Jul 12. Mol Pharmacol. 2010. PMID: 20624855

3

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

Takakusa H, Wahlin MD, Zhao C, Hanson KL, New LS, Chan EC, Nelson SD. Takakusa H, et al. Among authors: nelson sd. Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531. Epub 2011 Mar 1. Drug Metab Dispos. 2011. PMID: 21363997 Free PMC article.

4

Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells.

Hardy KD, Wahlin MD, Papageorgiou I, Unadkat JD, Rettie AE, Nelson SD. Hardy KD, et al. Among authors: nelson sd. Drug Metab Dispos. 2014 Jan;42(1):162-71. doi: 10.1124/dmd.113.054817. Epub 2013 Nov 4. Drug Metab Dispos. 2014. PMID: 24191259 Free PMC article.

5

Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.

Harrelson JP, Stamper BD, Chapman JD, Goodlett DR, Nelson SD. Harrelson JP, et al. Among authors: nelson sd. Drug Metab Dispos. 2012 Aug;40(8):1460-5. doi: 10.1124/dmd.112.045492. Epub 2012 May 21. Drug Metab Dispos. 2012. PMID: 22613176

6

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.

Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD. Dong H, et al. Among authors: nelson sd. Drug Metab Dispos. 2000 Dec;28(12):1397-400. Drug Metab Dispos. 2000. PMID: 11095574

7

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6.

Khojasteh-Bakht SC, Koenigs LL, Peter RM, Trager WF, Nelson SD. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Drug Metab Dispos. 1998 Jul;26(7):701-4. Drug Metab Dispos. 1998. PMID: 9660853

8

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

Nelson SD, Trager WF. Nelson SD, et al. Drug Metab Dispos. 2003 Dec;31(12):1481-98. doi: 10.1124/dmd.31.12.1481. Drug Metab Dispos. 2003. PMID: 14625345 Review.

9

Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes.

Lee CA, Manyike PT, Thummel KE, Nelson SD, Slattery JT. Lee CA, et al. Among authors: nelson sd. Drug Metab Dispos. 1997 Oct;25(10):1150-6. Drug Metab Dispos. 1997. PMID: 9321518

10

Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity.

Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, Bruschi SA. Ho HK, et al. Among authors: nelson sd. Toxicol Sci. 2005 Aug;86(2):354-64. doi: 10.1093/toxsci/kfi205. Epub 2005 May 18. Toxicol Sci. 2005. PMID: 15901913

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