Bierbach U - Search Results

1

Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.

Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U. Qiao X, et al. Among authors: bierbach u. Metallomics. 2012 Jul;4(7):645-52. doi: 10.1039/c2mt20031g. Epub 2012 Mar 29. Metallomics. 2012. PMID: 22456976 Free PMC article.

2

Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore.

Martins ET, Baruah H, Kramarczyk J, Saluta G, Day CS, Kucera GL, Bierbach U. Martins ET, et al. Among authors: bierbach u. J Med Chem. 2001 Dec 6;44(25):4492-6. doi: 10.1021/jm010293m. J Med Chem. 2001. PMID: 11728195

3

Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates.

Baruah H, Rector CL, Monnier SM, Bierbach U. Baruah H, et al. Among authors: bierbach u. Biochem Pharmacol. 2002 Jul 15;64(2):191-200. doi: 10.1016/s0006-2952(02)01107-3. Biochem Pharmacol. 2002. PMID: 12123739

4

Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate.

Barry CG, Turney EC, Day CS, Saluta G, Kucera GL, Bierbach U. Barry CG, et al. Among authors: bierbach u. Inorg Chem. 2002 Dec 30;41(26):7159-69. doi: 10.1021/ic025744n. Inorg Chem. 2002. PMID: 12495358

5

Bis(acridinylthiourea)platinum(II) complexes: synthesis, DNA affinity, and biological activity in glioblastoma cells.

Augustus TM, Anderson J, Hess SM, Bierbach U. Augustus TM, et al. Among authors: bierbach u. Bioorg Med Chem Lett. 2003 Mar 10;13(5):855-8. doi: 10.1016/s0960-894x(02)01078-8. Bioorg Med Chem Lett. 2003. PMID: 12617907

6

Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agent.

Barry CG, Baruah H, Bierbach U. Barry CG, et al. Among authors: bierbach u. J Am Chem Soc. 2003 Aug 13;125(32):9629-37. doi: 10.1021/ja0351443. J Am Chem Soc. 2003. PMID: 12904029

7

Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer.

Baruah H, Bierbach U. Baruah H, et al. Among authors: bierbach u. J Biol Inorg Chem. 2004 Apr;9(3):335-44. doi: 10.1007/s00775-004-0534-3. Epub 2004 Mar 16. J Biol Inorg Chem. 2004. PMID: 15024635

8

Structure-activity relationships in platinum-acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity.

Ackley MC, Barry CG, Mounce AM, Farmer MC, Springer BE, Day CS, Wright MW, Berners-Price SJ, Hess SM, Bierbach U. Ackley MC, et al. Among authors: bierbach u. J Biol Inorg Chem. 2004 Jun;9(4):453-61. doi: 10.1007/s00775-004-0541-4. Epub 2004 Apr 6. J Biol Inorg Chem. 2004. PMID: 15067524

9

Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent.

Baruah H, Day CS, Wright MW, Bierbach U. Baruah H, et al. Among authors: bierbach u. J Am Chem Soc. 2004 Apr 14;126(14):4492-3. doi: 10.1021/ja038592j. J Am Chem Soc. 2004. PMID: 15070347

10

Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin.

Budiman ME, Alexander RW, Bierbach U. Budiman ME, et al. Among authors: bierbach u. Biochemistry. 2004 Jul 6;43(26):8560-7. doi: 10.1021/bi049415d. Biochemistry. 2004. PMID: 15222767

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