Kelleher NL - Search Results

1

Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.

Vagstad AL, Bumpus SB, Belecki K, Kelleher NL, Townsend CA. Vagstad AL, et al. Among authors: kelleher nl. J Am Chem Soc. 2012 Apr 18;134(15):6865-77. doi: 10.1021/ja3016389. Epub 2012 Apr 9. J Am Chem Soc. 2012. PMID: 22452347 Free PMC article.

2

Kinetic and regiospecific interrogation of covalent intermediates in the nonribosomal peptide synthesis of yersiniabactin.

McLoughlin SM, Kelleher NL. McLoughlin SM, et al. Among authors: kelleher nl. J Am Chem Soc. 2004 Oct 20;126(41):13265-75. doi: 10.1021/ja0470867. J Am Chem Soc. 2004. PMID: 15479080 Free PMC article.

3

Monitoring multiple active sites on thiotemplate enzymes in parallel: a molecular movie of yersiniabactin bioassembly.

McLoughlin SM, Kelleher NL. McLoughlin SM, et al. Among authors: kelleher nl. J Am Chem Soc. 2005 Nov 2;127(43):14984-5. doi: 10.1021/ja0555264. J Am Chem Soc. 2005. PMID: 16248611

4

Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster.

Aron ZD, Dorrestein PC, Blackhall JR, Kelleher NL, Walsh CT. Aron ZD, et al. Among authors: kelleher nl. J Am Chem Soc. 2005 Nov 2;127(43):14986-7. doi: 10.1021/ja055247g. J Am Chem Soc. 2005. PMID: 16248612

5

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.

Dorrestein PC, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Dorrestein PC, et al. Among authors: kelleher nl. Biochemistry. 2006 Oct 24;45(42):12756-66. doi: 10.1021/bi061169d. Biochemistry. 2006. PMID: 17042494 Free PMC article.

6

Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display.

Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT. Yin J, et al. Among authors: kelleher nl. Chem Biol. 2007 Mar;14(3):303-12. doi: 10.1016/j.chembiol.2007.01.006. Chem Biol. 2007. PMID: 17379145

7

The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity.

Hansen DB, Bumpus SB, Aron ZD, Kelleher NL, Walsh CT. Hansen DB, et al. Among authors: kelleher nl. J Am Chem Soc. 2007 May 23;129(20):6366-7. doi: 10.1021/ja070890j. Epub 2007 May 2. J Am Chem Soc. 2007. PMID: 17472382 No abstract available.

8

Deconstruction of iterative multidomain polyketide synthase function.

Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA. Crawford JM, et al. Among authors: kelleher nl. Science. 2008 Apr 11;320(5873):243-6. doi: 10.1126/science.1154711. Science. 2008. PMID: 18403714 Free PMC article.

9

Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis.

Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT. Bumpus SB, et al. Among authors: kelleher nl. J Am Chem Soc. 2008 Sep 3;130(35):11614-6. doi: 10.1021/ja8040042. Epub 2008 Aug 12. J Am Chem Soc. 2008. PMID: 18693732 Free PMC article.

10

Accessing natural product biosynthetic processes by mass spectrometry.

Bumpus SB, Kelleher NL. Bumpus SB, et al. Among authors: kelleher nl. Curr Opin Chem Biol. 2008 Oct;12(5):475-82. doi: 10.1016/j.cbpa.2008.07.022. Curr Opin Chem Biol. 2008. PMID: 18706516 Free PMC article. Review.

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