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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.
Yang J, Ferreira T, Morris AP, Medland SE; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Madden PA, Heath AC, Martin NG, Montgomery GW, Weedon MN, Loos RJ, Frayling TM, McCarthy MI, Hirschhorn JN, Goddard ME, Visscher PM. Yang J, et al. Among authors: weedon mn. Nat Genet. 2012 Mar 18;44(4):369-75, S1-3. doi: 10.1038/ng.2213. Nat Genet. 2012. PMID: 22426310 Free PMC article.
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM. Gloyn AL, et al. Among authors: weedon mn. Diabetes. 2003 Feb;52(2):568-72. doi: 10.2337/diabetes.52.2.568. Diabetes. 2003. PMID: 12540637
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
Weedon MN, Schwarz PE, Horikawa Y, Iwasaki N, Illig T, Holle R, Rathmann W, Selisko T, Schulze J, Owen KR, Evans J, Del Bosque-Plata L, Hitman G, Walker M, Levy JC, Sampson M, Bell GI, McCarthy MI, Hattersley AT, Frayling TM. Weedon MN, et al. Am J Hum Genet. 2003 Nov;73(5):1208-12. doi: 10.1086/379285. Am J Hum Genet. 2003. PMID: 14574648 Free PMC article. No abstract available.
309 results