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Page 1
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Schlemminger I, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. doi: 10.1016/s0960-894x(03)00149-5. Bioorg Med Chem Lett. 2003. PMID: 12668010
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492
Enzymatic synthesis of monocyclic beta-lactams.
Sleeman MC, MacKinnon CH, Hewitson KS, Schofield CJ. Sleeman MC, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2002 Feb 25;12(4):597-9. doi: 10.1016/s0960-894x(01)00806-x. Bioorg Med Chem Lett. 2002. PMID: 11844680
The HIF pathway as a therapeutic target.
Hewitson KS, Schofield CJ. Hewitson KS, et al. Drug Discov Today. 2004 Aug 15;9(16):704-11. doi: 10.1016/S1359-6446(04)03202-7. Drug Discov Today. 2004. PMID: 15341784 Review.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. McDonough MA, et al. Among authors: hewitson ks. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. doi: 10.1073/pnas.0601283103. Epub 2006 Jun 16. Proc Natl Acad Sci U S A. 2006. PMID: 16782814 Free PMC article.
47 results