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Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504).
Kent LM, Smyth LJ, Plumb J, Clayton CL, Fox SM, Ray DW, Farrow SN, Singh D. Kent LM, et al. Among authors: plumb j. J Pharmacol Exp Ther. 2009 Feb;328(2):458-68. doi: 10.1124/jpet.108.142950. Epub 2008 Nov 12. J Pharmacol Exp Ther. 2009. PMID: 19004925 Free PMC article.
COPD monocytes demonstrate impaired migratory ability.
Ravi AK, Plumb J, Gaskell R, Mason S, Broome CS, Booth G, Catley M, Vestbo J, Singh D. Ravi AK, et al. Among authors: plumb j. Respir Res. 2017 May 11;18(1):90. doi: 10.1186/s12931-017-0569-y. Respir Res. 2017. PMID: 28494757 Free PMC article.
377 results